Surge protector: A novel approach to suppressing therapy-induced tumor growth and recurrence

Following up on a groundbreaking 2018 study in which BIDMC's Dipak Panigrahy, MD, demonstrated that dead and dying cancer cells killed by conventional cancer treatments paradoxically trigger inflammation that promotes tumor growth and metastasis, a new study led by Allison Gartung, Ph.D., describes a novel approach to suppressing chemotherapy-induced tumor growth in an ovarian cancer model. Gartung and colleagues' findings were published in published in January in Proceedings of the National Academy of Science (PNAS).

Working in a mouse model of the disease, the team confirmed that chemotherapy-killed ovarian induce surrounding called macrophages to release a surge of chemicals. Together, these chemicals, known as cytokines and , create an environment conducive to and survival.

"Conventional cancer therapy is a double-edged sword—the very treatment meant to control cancer is also helping it to survive and grow," said Gartung, a postdoctoral fellow in BIDMC's Department of Pathology. "To prevent tumor recurrence after therapy, it is critical to neutralize the inherent tumor-promoting activity of therapy-generated debris."

Next, the team showed that a newly synthesized anti-inflammatory drug called PTUPB—specifically designed to target the chemical pathways that lead to cytokines and lipid mediators—blocks the debris-stimulated surge of tumor-promoting chemicals by macrophages. In addition, the scientists found that PTUPB prolonged survival in mice bearing ovarian tumors and suppressed debris-stimulated tumor growth.

"The role of these chemotherapy-induced cytokines and lipids is underappreciated and poorly characterized, and ovarian cancer patients may benefit from suppressing their release," said Panigrahy, Assistant Professor of Pathology and a Scientist at the Cancer Center at BIDMC. "Further research is needed but, our results indicate that PTUPB may compliment conventional cancer therapies by acting as a 'surge protector' against cell debris-stimulated tumor growth."


Explore further

Study reveals cancer therapy's double-edged sword... and how to blunt it

More information: Allison Gartung el al., "Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor," PNAS (2018). www.pnas.org/cgi/doi/10.1073/pnas.1803999116
Citation: Surge protector: A novel approach to suppressing therapy-induced tumor growth and recurrence (2019, January 15) retrieved 3 December 2021 from https://medicalxpress.com/news/2019-01-surge-protector-approach-suppressing-therapy-induced.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors