Osteoblastic cell stimulation by pulsed electromagnetic fields

Osteoblastic cell stimulation by pulsed electromagnetic fields
Credit: Mary Ann Liebert, Inc., publishers

Bone fracture healing can be augmented with the application of pulsed electromagnetic fields (PEMFs), but a consensus regarding idealized conditions is lacking. A new study characterizes the in vitro effects of these PEMFs on the crucial osteoblast precursor cells and seeks to determine the optimal conditions that will promote bone regeneration. The study is published in Tissue Engineering.

Swee-Hin Teoh, Nanyang Technological University, Singapore, presents his work with colleagues in an article titled "Effects of Electromagnetic Field on Proliferation, Differentiation and Mineralization of MC3T3 Cells". The authors applied a daily controlled dose of pulsed in varying duration to MC3T3-E1 osteoblast precursor cells and monitored cell viability and metabolic activity. This analysis revealed that the PEMFs increased cell proliferation either with or without osteogenic media. Calcium deposition was not enhanced by the PEMF, but osteogenic gene expression was induced. The study demonstrates that PEMF parameters must be chosen carefully to produce the desired effects for .

"This study confirms that pulsed electromagnetic field have indeed potential for application in bone regeneration, but the data emphasized also that a carefull selection of the PEMF parameters is required to induce a favorable effect," says Tissue Engineering Methods Co-Editor-In-Chief Editor John A. Jansen, DDS, Ph.D., Professor and Head, Department of Biomaterials, Radboud University Medical Center.


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More information: Luvita Suryani et al, Effects of Electromagnetic Field on Proliferation, Differentiation, and Mineralization of MC3T3 Cells, Tissue Engineering Part C: Methods (2019). DOI: 10.1089/ten.tec.2018.0364
Citation: Osteoblastic cell stimulation by pulsed electromagnetic fields (2019, March 27) retrieved 22 October 2019 from https://medicalxpress.com/news/2019-03-osteoblastic-cell-pulsed-electromagnetic-fields.html
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