Researchers develop treatment that turns tumors into cancer vaccine factories

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Researchers at Mount Sinai have developed a novel approach to cancer immunotherapy, injecting immune stimulants directly into a tumor to teach the immune system to destroy it and other tumor cells throughout the body.

The "in situ vaccination" worked so well in patients with advanced-stage lymphoma that it is also undergoing trials in breast and head and neck cancer patients, according to a study published in Nature Medicine in April.

The treatment consists of administering a series of immune stimulants directly into one tumor site. The first stimulant recruits important immune cells called dendritic cells that act like generals of the immune army. The second stimulant activates the dendritic cells, which then instruct T cells, the 's soldiers, to kill cancer cells and spare non-. This immune army learns to recognize features of the so it can seek them out and destroy them throughout the body, essentially turning the tumor into a cancer vaccine factory.

"The in situ vaccine approach has broad implications for multiple types of cancer," said lead author Joshua Brody, MD, Director of the Lymphoma Immunotherapy Program at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. "This method could also increase the success of other immunotherapies such as checkpoint blockade."

After testing the lymphoma vaccine in the lab, it was tested in 11 patients in a clinical trial. Some patients had full remission from months to years. In in mice, the vaccine drastically increased the success of checkpoint blockade immunotherapy, the type of immunotherapy responsible for the complete remission of former President Jimmy Carter's cancer and the focus of the 2018 Nobel Prize in Medicine.

A clinical trial for lymphoma, breast, and head and neck cancer patients opened in March to test the vaccine with checkpoint blockade drugs. Because the combined immune therapy was at least three times more powerful than either or the vaccine by themselves, researchers are extremely optimistic about how effective this may be in patients in this new trial. The in situ vaccine is also being tested in the lab in liver and ovarian cancer.


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More information: Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination, Nature Medicine (2019). DOI: 10.1038/s41591-019-0410-x , https://www.nature.com/articles/s41591-019-0410-x
Journal information: Nature Medicine

Citation: Researchers develop treatment that turns tumors into cancer vaccine factories (2019, April 8) retrieved 18 April 2019 from https://medicalxpress.com/news/2019-04-treatment-tumors-cancer-vaccine-factories.html
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Apr 08, 2019
Just think. In 20 years we may see this actually healing people. Now if we could heal the bureaucracy that keeps it from moving forward, we could maybe see it in 5 years.

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