Cancer device created to see if targeted chemotherapy is working

Cancer device created at rutgers to see if targeted chemotherapy is working
Six devices with biosensors to detect whether a cancer cell is alive when it passes through a tiny hole for fluids. The devices fit on a 3-inch wide piece of glass. Credit: Zhongtian Lin

Rutgers researchers have created a device that can determine whether targeted chemotherapy drugs are working on individual cancer patients.

The , which uses and biosensors, is up to 95.9 percent accurate in counting live when they pass through electrodes, according to a study in the journal Microsystems & Nanoengineering.

"We built a portable platform that can predict whether patients will respond positively to targeted ," said senior author Mehdi Javanmard, an assistant professor in the Department of Electrical and Computer Engineering in the School of Engineering at Rutgers University-New Brunswick. "Our technology combines artificial intelligence and sophisticated biosensors that handle tiny amounts of fluids to see if cancer cells are sensitive or resistant to ."

The device provides immediate results and will allow for more personalized interventions for patients as well as better management and detection of the disease. It can rapidly analyze cells without having to stain them, allowing for further molecular analysis and instantaneous results. Current devices rely on staining, limiting the characterization of cells.

"We envision using this new device as a point-of-care diagnostic tool for assessing patient response and personalization of therapeutics," the study says.

Treatment of cancer patients often requires drugs that can kill tumor cells, but chemotherapy destroys both tumor cells and healthy cells, causing side effects such as and gastrointestinal problems.

Co-author Joseph R. Bertino, a resident researcher at Rutgers Cancer Institute of New Jersey and professor at Rutgers Robert Wood Johnson Medical School, and his team previously developed a therapeutic approach that targets cancer cells, such as those in B-cell lymphoma, multiple myeloma and epithelial carcinomas. It binds a chemotherapy drug to an antibody so only tumor cells are targeted, and minimizes interaction with . Patients will respond positively to this therapy if their generate a protein called matriptase. Many patients will benefit while the side effects from standard chemotherapy are minimized.

"Novel technologies like this can really have a positive impact on the standard-of-care and result in cost-savings for both healthcare providers and patients," Bertino said.

The Rutgers team tested their new device using cancer cell samples treated with different concentrations of a targeted anti­cancer drug. The device detects whether a cell is alive based on the shift in its electrical properties as it passes through a tiny fluidic hole. The next step is to perform tests on tumor samples from patients. The researchers hope the device will eventually be used to test cancer therapies on samples of patient tumors before treatment is administered.


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More information: Karan Ahuja et al, Toward point-of-care assessment of patient response: a portable tool for rapidly assessing cancer drug efficacy using multifrequency impedance cytometry and supervised machine learning, Microsystems & Nanoengineering (2019). DOI: 10.1038/s41378-019-0073-2
Provided by Rutgers University
Citation: Cancer device created to see if targeted chemotherapy is working (2019, July 16) retrieved 22 August 2019 from https://medicalxpress.com/news/2019-07-cancer-device-rutgers-chemotherapy.html
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