Gene protective against fruit fly heat-induced seizures may explain some human seizures

Gene protective against fruit fly heat-induced seizures may explain some human seizures
A gene that encode an ion channel enables flies to resist the effects of acute heat stress. As suggested by its name, mutation in the gene seizure (sei for short) cause flies to become highly sensitive to heat stress. When ambient temperature goes up rapidly, wild type flies are able to escape these unfavorable conditions. In contrast, mutant flies are hypersensitive to heat and start seizing almost immediately. Hill et al. now show that the protective effect of sei comes from its activity in specific populations and neurons and glia cells in the fly brain. Shown are the neurons in the ventral ganglion of the fly (a structure homologous to the spinal cord), which express the sei protein (green). All other neurons are shown in magenta. The nuclei of all cells in the nerve cord are in blue. Credit: Dr. Alexis Hill

Researchers identified a gene in fruit flies that helps prevent the hyperexcitability of specific neurons that trigger seizures. In humans, mutations in the gene may be linked to seizures associated with Long QT Syndrome. A research team led by Yehuda Ben-Shahar of Washington University in St. Louis report these findings in a paper published 8th August in PLOS Genetics.

The can be highly sensitive to such as swings in temperature or oxygen levels. These environmental stresses are known to cause seizures, but scientists have little understanding of the genetic and molecular causes behind them. Using , researchers investigated certain proteins, called ion channels, involved in passing electrical signals between neurons and other cells. They studied a fly gene necessary to block stress-induced seizures, called sei, which functions throughout the nervous system and in the heart. They found that sei primarily protects against heat-induced seizures through its action in specific cell types in the nervous system, but that blocking the gene in the heart had no effect.

Humans have a comparable gene called hERG and previous work has linked mutations in hERG to a condition called Long QT Syndrome, where a sudden erratic heart beat can lead to fainting spells, seizures and potentially even death. The discovery raises the possibility that seizures associated with Long QT Syndrome are related to problems with hERG, not in the heart, but in the brain.

"Individuals with mutations in the potassium channel hERG suffer from seizures, which are often assumed to be a secondary consequence of heart disease," said author Yehuda Ben-Shahar. "Here we have identified a role for the fly version of the hERG gene in specific brain cell types in preventing the development of seizures in response to acute environmental stresses. We plan to continue using the fruit fly as a model system for investigating the genetic and physiological networks that protect the brain from stress-induced hyperexcitability associated with seizures and related pathologies."

The new study provides compelling evidence that hERG play an essential role in protecting the nervous system from , such as heat. It may also give insight into the mechanisms behind diseases associated with hERG mutations in human patients.

More information: Alexis S. Hill et al, The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response, PLOS Genetics (2019). DOI: 10.1371/journal.pgen.1008288

Journal information: PLoS Genetics

Citation: Gene protective against fruit fly heat-induced seizures may explain some human seizures (2019, August 8) retrieved 23 March 2023 from
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