Lack of oxygen doesn't kill infant brain cells, as previously thought

Lack of oxygen doesn't kill infant brain cells, as previously thought
Stephen Back, M.D., Ph.D., Clyde and Elda Munson Professor of Pediatric Research, OHSU School of Medicine, OHSU Doernbecher Children's Hospital, and team determined that hypoxia doesn't kill infant brain cells, and impact may be restored. Credit: OHSU

Nearly 15 million babies are born prematurely, or before 37 weeks of pregnancy, around the world each year. When born too early, a baby's immature respiratory center in the brain often fails to signal it to breathe, resulting in low oxygen levels, or hypoxia, in the brain.

Research published in the Journal of Neuroscience shows that even a brief 30-minute period of is enough to persistently disrupt the structure and function of the brain region known as the hippocampus, which is vital for learning and memory.

"Our findings raise new concerns about the vulnerability of the preterm brain to hypoxia. They are concerning for the long-term impact that oxygen deprivation can have on the ability of these preterm babies to learn as they grow to and adulthood," said the study's principal investigator, Stephen Back, M.D., Ph.D., Clyde and Elda Munson Professor of Pediatric Research and Pediatrics, OHSU School of Medicine, OHSU Doernbecher Children's Hospital.

In the , preemies can experience up to 600 short, but impactful periods of hypoxia each week. Consequently, more than one-third of babies who survive are likely to have smaller brains, presumably due to brain cell loss, compared with the brains of full-term infants. This can increase the risk of significant life-long neurodevelopmental challenges that will affect learning, memory, attention and behavior.

Using a twin preterm fetal sheep model, Back and colleagues studied the impact of both hypoxia alone, as well as in combination with ischemia—or insufficient blood flow—on the developing hippocampus. The results confirm that, similar to human preterm survivors, growth of the hippocampus is impaired. However, do not die as previously believed. Rather, hippocampal cells fail to mature normally, causing a reduction in long-term potentiation, or the cellular basis of how the learns.

Remarkably, the severity of the hypoxia predicted the degree to which cells in the hippocampus failed to mature normally, explains Back. These findings are all the more unexpected because it was not appreciated that the preterm hippocampus was already capable of these learning processes.

"We want to understand next how very brief or prolonged exposure to hypoxia affects the ability for optimal learning and memory, " says Back. "This will allow us to understand how the hippocampus responds to a lack of oxygen, creating new mechanisms of care and intervention both at the hospital, and at home."


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Lack of oxygen, not blood flow, delays brain maturation in preterm infants

More information: Evelyn McClendon et al, Transient Hypoxemia Disrupts Anatomical and Functional Maturation of Preterm Fetal Ovine CA1 Pyramidal Neurons, The Journal of Neuroscience (2019). DOI: 10.1523/JNEUROSCI.1364-19.2019
Journal information: Journal of Neuroscience

Citation: Lack of oxygen doesn't kill infant brain cells, as previously thought (2019, August 29) retrieved 23 September 2019 from https://medicalxpress.com/news/2019-08-lack-oxygen-doesnt-infant-brain.html
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