Map showing gene interactions could lead to new cancer therapies

Map showing gene interactions could lead to new cancer therapies
This plot shows the Epstein-Barr virus integration into the human genome in cancer patients. Credit: Purdue University

Nearly 150,000 cancer-related deaths can be attributed annually to Epstein-Barr (EBV) virus, in part because of the lack of effective treatment options.

Now, a research team has created the first comprehensive map of interactions between the genes of the virus and host in EBV-associated cancers, knowledge that could lead to new treatments. The research is a collaboration of scientists from Purdue University, the National Institutes of Health and Harvard University.

The research team has created an "interactome map," which shows how the expression, mutation and integration of viral genes affect the host genes and vice versa.

"In this collaboration between the Purdue University Center for Cancer Research, the NIH's National Institute of Diabetes and Digestive and Kidney Diseases, and Harvard University, we developed the first comprehensive map of interactions between Epstein-Barr virus and host cells in EBV-associated cancers," said Majid Kazemian, an assistant professor in Purdue's departments of Biochemistry and Computer science. "The governing Epstein-Barr virus's carcinogenesis remain elusive, and the functional interactions between virus and host cells are incompletely defined. Here, we present a comprehensive map showing the interactions of and pathogen genes in EBV-associated cancers."

Research findings were published online Sept. 3 in the journal Cancer Research. The paper's lead author was Purdue biochemistry graduate student Srishti Chakravorty.

The Epstein-Barr virus is ubiquitous, infecting approximately 90 percent of the world's adult population. In its latent stage, the virus causes a wide range of cancers. Over the five decades since the discovery of this multi-disease associated oncovirus, various aspects of its life cycle and host immune response in individual tumor types or cell lines have been studied.

"However, generalized host-virus interactions in a large cohorts of patients have not been systematically delineated," Kazemian said.

The researchers systematically analyzed genetic sequencing from more than 1,000 patients with 15 different cancer types.

"Overall, these findings uncover novel points of interaction between a common oncovirus and the human genome and identify new regulatory nodes and druggable targets for individualized EBV and cancer-specific therapies," Kazemian said.

The research is ongoing.

"One of the major directions that we are taking is to determine whether we could manipulate an EBV gene to make cancer cells more sensitive to immunotherapy," he said.

Explore further

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More information: Srishti Chakravorty et al. Integrated pan-cancer map of EBV-associated neoplasms reveals functional host-virus interactions, Cancer Research (2019). DOI: 10.1158/0008-5472.CAN-19-0615
Journal information: Cancer Research

Provided by Purdue University
Citation: Map showing gene interactions could lead to new cancer therapies (2019, October 1) retrieved 14 November 2019 from
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