The 'signal cell' relaying microbiota signals discovered

Credit: CC0 Public Domain

Microorganisms are considered dirty organism that threaten our health, decay food and cause inconvenience in our daily life. However, they are playing a critical role in making nutrients by metabolizing food, allowing all living creatures to live on. There are 2,000 kinds of microorganisms and several hundred trillions living in our body. Most of these microorganisms live in the digestive tract but their effect is evident in our entire body. Recently, a research team from POSTECH (Pohang University of Science and Technology, President Moohwan Kim) discovered how microbiota transmit signals through the entire body and control hematopoiesis in the bone marrow.

Professor Seung-Woo Lee, Research Professor Yunji Park, and integrated program students, Seungwon Lee and Hyekang Kim of Division of Integrative Biosciences and Biotechnology from POSTECH described the mechanism how microbiota signals are sent to different organs. Also, they utilized imaging research to prove that CX3CR+ mononuclear cells contact hematopoietic progenitors for the first time. Their research is introduced as featured content in the journal of the American Society of Hematology, Blood.

Recent research on microorganisms concluded that microbiota control biological phenomena not only in the digestive tract but also in lung, liver, brain, bone marrow and other organs. But no research was able to define a mechanism for relaying microbiota signals to the entire or for producing by receiving microbiota signals.

Professor Lee and his research team focused on the fact that the microbiota regulate the immune system of our body by controlling hematopoiesis in the bone marrow to produce white blood cells. In this process, the team discovered that the microbiota signal including bacterial DNA is transferred to the bone marrow through the bloodstream and CX3CR1+ mononuclear cells in the bone marrow recognize this signal.

The 'Signal Cell' relaying microbiota signals discovered
CX3CR1+ mononuclear cells (colored in green) are contacting hematopoietic progenitors (colored in purple) in the bone marrow. When CX3CR1+ mononuclear cells recognize the microbiota signals, they produce inflammatory cytokines which expedite the hematopoiesis. Credit: POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY (POSTECH)

They explained that when CX3CR1+ mononuclear cells recognize microbiota signals, they release signal substances called cytokines which control and stimulate the body's defense system through signal transduction. They also explained that cytokines control the number of hematopoietic progenitors or stimulate differentiation into myeloid lineages to make blood cells.

Furthermore, they verified that CX3CR1+ mononuclear contact hematopoietic progenitors at the perivascular region and they function as a signal, also receiving microbiota signals.

They discovered the hematopoiesis control mechanism which is controlled by cytokines produced when CX3CR1+ recognize microbiota signals transferred to the .

Professor Seung-Woo Lee commented, "For the first time, our research describes the mechanism that had not been explained how microbiota regulate not only digestive tracts but also entire body response. It might be possible to apply this study to control immune response in other parts of a body or to treat cancer and inflammatory disease via signal pathway.

More information: Seungwon Lee et al. Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice, Blood (2019). DOI: 10.1182/blood.2019000495
Journal information: Blood

Provided by Pohang University of Science & Technology (POSTECH)
Citation: The 'signal cell' relaying microbiota signals discovered (2019, November 25) retrieved 9 December 2022 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Transient wave of hematopoietic stem cell production in late fetuses and young adults


Feedback to editors