Ultrasound treatment for essential tremor may be effective up to three years later

People with tremors in their hands, head or voice may find some relief for up to three years from a treatment using ultrasound waves to destroy the area of the brain causing the tremor, according to a study published in the November 20, 2019, online issue of Neurology, the medical journal of the American Academy of Neurology. The treatment is used for people whose tremors do not improve with medication.

Essential tremor is the most common type of tremor disorder. It can be disabling for the over 7 million people in the United States living with the disorder. The condition may cause problems with such as eating, writing or shaving.

"For people who have disabling that is not responding to medication, this treatment should be considered as a safe and effective option," said study author Casey H. Halpern, MD, of Stanford University in Stanford, Calif.

The study involved 76 people with an average age of 71 who had essential tremor for an average of 17 years. In the initial study, 56 people received the treatment, which is called focused ultrasound thalamotomy, and 20 people had a sham therapy. After three months, participants were told whether they received the treatment or the sham and those who received the sham were allowed to have the treatment. All participants were then followed for two years. The current study followed the participants for an additional year after the treatment.

Hand tremors, level of disability and were measured at the start of the study, after six months, one year, two years and three years.

After three years, on average, the participants improved in hand tremors by 50 percent, disability by 56 percent, and quality of life by 42 percent.

No new side effects occurred during the third year after treatment. None of the side effects worsened and two were resolved. All side effects in the study were mild or moderate. They included numbness and tingling, imbalance and unsteadiness.

Compared to the scores six months after treatment, hand tremors and disability increased slightly after three years. On a scale of zero to 32, hand tremor scores initially were an average of 20. At six months average scores were nine and by three years were 10. For disability, on a scale of zero to 32, scores were initially an average of 16. At six months, scores were an average of four and at three years an average of six.

The current most frequent treatment for people with severe essential tremor responding insufficiently to medication is deep brain stimulation. Halpern said while the study did not compare the two treatments, the focused ultrasound thalamotomy offers several advantages to deep brain stimulation. "This is a less invasive treatment that does not involve incisions or inserting probes or electrodes into the brain. It is performed in one session; there is no need for follow-up visits. And the benefit is immediate." At the same time, this treatment, in contrast to , does produce a lesion and is not adjustable or reversible.

Halpern noted that because the people in the study and the researchers all knew that everyone was receiving the treatment, more research is needed with some people receiving a sham treatment to confirm these results.

A limitation of the study was that 23 people, or 31 percent, did not complete the entire three years. The researchers determined that those who later dropped out of the study were not responding as well to the treatment after three months as those who completed the study.


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Journal information: Neurology

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