Controlling molecular glue protects connections between brain cells

Controlling molecular glue protects connections between brain cells
Attachment sites (magenta) in the surrounding skin of roundworm nerve cells act as a glue, helping the cells remain intact during periods of strain. Credit: University of Queensland

A way in which some connections between brain cells can resist degeneration—a hallmark of traumatic brain injuries and neurodegenerative diseases—has been discovered by researchers at The University of Queensland.

Dr. Sean Coakley and Professor Massimo Hilliard from UQ's Queensland Brain Institute Clem Jones Centre for Ageing Dementia Research uncovered a way in which cells control the stickiness of a molecular glue that protects connections between brain cells and prevent neurodegeneration.

"Our communicate with one another via sent through long cable-like structures called which, just like electrical cables, need to be protected and maintained to work properly," Dr. Coakley said.

"Axons are only one 50th the width of a human hair, so are extremely vulnerable to damage—the loss of connections between neurons has devastating consequences for the brain."

Professor Hilliard said axons are under constant strain as the body moves, for example, in your legs and arms as they bend and stretch during everyday tasks.

"In the roundworm C. elegans, the axons that carry messages about the sense of touch are embedded in the skin of the worm, which we found actually serves to protect them and resist mechanical strain," Professor Hilliard said.

"The axon is glued to the surrounding skin and when this adhesion is faulty, the simple movement of the worm provides enough force to snap the axon in half."

Using a mix of genetics and , the researchers discovered a set of molecules that control the strength or 'stickiness' of this adhesion and are essential to preserve the structure and function of axons.

"Remarkably, these molecules are present in species throughout the , including mammals, which indicates they may perform a similar role," Dr. Coakley said.

"These molecules shed light on ways in which these fragile axons are protected from deterioration in healthy individuals and how that might go awry in disease states.

"Despite the description of axon degeneration more than 100 years ago, we are still striving to understand how these essential connections are kept intact."

This research was published in the journal Nature Communications.

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More information: Sean Coakley et al. Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration, Nature Communications (2020). DOI: 10.1038/s41467-019-13795-x
Journal information: Nature Communications

Citation: Controlling molecular glue protects connections between brain cells (2020, January 16) retrieved 5 July 2022 from
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