Psoriasis tied to higher Alzheimer disease risk

Psoriasis tied to higher alzheimer disease risk

(HealthDay)—The incidence of Alzheimer disease (AD) is significantly higher in patients with psoriasis versus individuals without psoriasis, according to a Korean study published online April 15 in Scientific Reports.

Miri Kim, from the Catholic University of Korea in Seoul, and colleagues used data from the Korean National Health Insurance System to identify 535,927 individuals with psoriasis and 2,679,635 age- and sex-matched controls without psoriasis who underwent at least three health examinations between 2008 and 2014. Risk for AD was assessed in the two groups.

The researchers found that during a median follow-up of 3.35 years, there were 50,209 cases of AD (1.87 percent) in controls versus 11,311 cases (2.11 percent) in patients with psoriasis. Patients with psoriasis showed a significantly increased risk for AD (hazard ratio [HR], 1.09; P < 0.0001) versus controls without psoriasis in adjusted models. The risk for AD among patients with psoriasis was significantly increased in psoriasis patients not receiving compared with those receiving systemic therapy (HR, 1.10; 95 percent confidence interval [CI], 1.08 to 1.12 versus HR, 0.99; 95 percent CI, 0.90 to 1.09; P < 0.0001).

"These results indicate that in may have an important impact on the and thus in increasing the risk of developing AD," the authors write.

More information: Abstract/Full Text (subscription or payment may be required)

Journal information: Scientific Reports

Copyright © 2020 HealthDay. All rights reserved.

Citation: Psoriasis tied to higher Alzheimer disease risk (2020, April 30) retrieved 22 May 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Familial psoriasis may not be tied to obesity


Feedback to editors