Antibiotics use early in life increases risk of inflammatory bowel disease later in life

Antibiotics use early in life increases risk of inflammatory bowel disease later in life
Martin Blaser, director of the Rutgers Center for Advanced Biotechnology and Medicine Credit: Rutgers University

Even short, single antibiotic courses given to young animals can predispose them to inflammatory bowel disease (IBD) when they are older, according to Rutgers researchers.

The study, published in Genome Medicine, provides further evidence supporting the idea that the use of in children under 1 year old disrupts the intestinal microbiota—the trillions of beneficial microorganisms that live in and on our bodies—that play a crucial role in the healthy maturation of the immune system and the prevention of diseases, such as and type 1 diabetes.

"This study provides strengthening the idea that the associations of antibiotic exposures to the later development of disease in are more than correlations, but that they are actually playing roles in the disease causation," said study co-author Martin Blaser, director of the Rutgers Center for Advanced Biotechnology and Medicine.

To determine if the increased disease risk was due to the disruption of the microbiome from antibiotics, the researchers studied the effects of exposure to dextran sulfate sodium, a chemical known to injure the colon, both in mice that received antibiotics, and in mice that had perturbed microbial contents transplanted into their intestines versus a control group.

They found that the mice that received either the antibiotics themselves or received the antibiotic-perturbed microbiome had significantly worse colitis, showing that exposure to antibiotics changed the microbiome, altered the in the colon and worsened the experimental colitis.

"The use of a well-validated model of colitis enabled us to study the effects of prior antibiotic exposures on the development of an important disease process," said lead author Ceren Ozkul, a visiting scholar from the Department of Pharmaceutical Microbiology at Hacettepe University in Turkey.

The study continues Blaser's work on the hypothesis that disrupting the early life microbiome, especially by antibiotics and C-section, is one of the factors driving modern epidemics.


Explore further

Antibiotics in early life slows digestive nerve function, alters microbiome

More information: Ceren Ozkul et al, A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis, Genome Medicine (2020). DOI: 10.1186/s13073-020-00764-z
Journal information: Genome Medicine

Provided by Rutgers University
Citation: Antibiotics use early in life increases risk of inflammatory bowel disease later in life (2020, July 29) retrieved 12 August 2020 from https://medicalxpress.com/news/2020-07-antibiotics-early-life-inflammatory-bowel.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
631 shares

Feedback to editors

User comments