Analysis reveals heart-related side effects of hydroxychloroquine and chloroquine

Analysis reveals heart-related side effects of hydroxychloroquine and chloroquine
As the antimalarial drugs hydroxychloroquine and chloroquine have drawn attention as potential therapies for COVID-19 and are being widely used off-label, it's now more important than ever to have a thorough assessment of the safety of these medications. A recent analysis published in the British Journal of Clinical Pharmacology provides new insights. Credit: Dr. Elad Maor

As the antimalarial drugs hydroxychloroquine and chloroquine have drawn attention as potential therapies for COVID-19 and are being widely used off-label, it's now more important than ever to have a thorough assessment of the safety of these medications. A recent analysis published in the British Journal of Clinical Pharmacology provides new insights.

In the analysis of real-world data from the Food and Drug Administration Adverse Events Reporting System, a global database of post-marketing safety reports, hydroxychloroquine and chloroquine were associated with higher rates of various cardiovascular problems, including life-threatening heart rhythm events, , and damage to the itself (termed cardiomyopathy).

"Moreover, we show how these adverse events carry high risks for severe outcomes including death, even with standard doses of the drugs," said senior author Elad Maor, MD, Ph.D., of Sheba Medical Center and Tel-Aviv University, in Israel. "The take-home message of our work is that physicians around the world should be careful when prescribing these drugs for off-label indications, especially for patients with cardiac disorders."


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More information: Adam Goldman et al, Cardiovascular adverse events associated with hydroxychloroquine and chloroquine: A comprehensive pharmacovigilance analysis of pre‐COVID‐19 reports, British Journal of Clinical Pharmacology (2020). DOI: 10.1111/bcp.14546
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Citation: Analysis reveals heart-related side effects of hydroxychloroquine and chloroquine (2020, September 23) retrieved 1 March 2021 from https://medicalxpress.com/news/2020-09-analysis-reveals-heart-related-side-effects.html
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