Multiple factors will influence pricing for COVID-19 vaccine in Canada, says health economist

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Conventional drug costing models are unlikely to apply when it comes to putting a price tag on a vaccine against COVID-19 for Canadians, according to health economist Christopher McCabe of the University of Alberta's Faculty of Medicine & Dentistry, who also heads Alberta's Institute of Health Economics.

"When you have an infection that is endemic in the population, what you need is for the to achieve herd immunity, and that means you need to get between 60 and 80 percent of the current population vaccinated," McCabe said. "If you can't afford to buy it at the level that would achieve herd immunity and the public is paying to get to herd immunity, then the value is a lot less."

McCabe noted that the standard estimate to research and develop a new drug is US$1.3 billion, based on work developed by Tufts University. That number takes into account the of the nearly 90 percent of prospective drugs that never make it to market.

McCabe stated that with a vaccine to sell would be better off seeing it as a kind of "loss leader" to get the economy restarted.

"The value of making sure your vaccine is widely used is in part so you can subsequently sell your other drugs that you've been investing in developing, because the economy is functioning again," McCabe said.

"Drug companies would be ill advised, from basic self-interest, to price at a level that gets in the way of herd immunity," said McCabe, who chairs the Royal Society of Canada COVID Task Force working group on the economy. "I would be encouraging government price negotiators to point that out to them."

Canada versus the U.S.

With more than 100 vaccine projects underway around the world, and nearly 30 already in , several countries including the United States and many in Europe have placed pre-orders for hundreds of millions of doses of the most promising drugs, in hopes of being able to start widespread immunization by the end of this year. Last month, Canada announced deals with potential vaccine suppliers Pfizer, Moderna, Johnson & Johnson and Novovax and is negotiating with others, but has not revealed any information about pricing.

In the U.S., where individuals or their insurance companies will bear the cost of immunization, estimates of the cost per dose range from $20 to $145, which would put the price for enough doses for 37.6 million Canadians near C$4 billion at the low end, close to 10 percent of the total bill for pharmaceuticals in Canada each year, McCabe said. But he predicted the calculation will be very different in Canada, where purchases will be made by the public health-care system.

"This is a very complex value proposition to understand," McCabe said. "What is the relationship between different levels of coverage of the population and the reduction in the risk of having another outbreak, with all the economic dislocation that comes with that?"

Part of that value will be based on how effective the vaccine is at preventing infection and how long that immunity might last, he said.

"If it's not going to be sustained immunity to the individual, then achieving becomes the better strategy from the individual's perspective," McCabe explained. "If it's like the that's really a one-season treatment, then the sustainable price will likely be a lot lower."

Competitive pressures

To date, Canada has approved just one drug, remdesivir, to treat patients with severe COVID-19 symptoms, after it was shown in a U.S. study to reduce recovery time by 31 percent. But McCabe expects more antiviral drugs to be available soon, and they will place further downward pressure on the value of any potential vaccine, because while treatments won't stop the virus from spreading, they would make it less deadly—and therefore less costly—to individuals, health-care systems and economies.

He said that even non-pharmaceutical measures such as wearing protective masks may, with further study, prove to be effective and relatively inexpensive strategies for governments looking to fight back against COVID-19.

"Governments are reluctant to go against the individual liberty lobby without that strong evidence, but when the evidence comes through, then I suspect they will be willing to mandate masking and that will make a big difference," McCabe said.

"If masking can get infection rates down to a level where the economy can return to something approximating normal, people can get back to work, schools can reopen and the payoff from a vaccine becomes a lot less," he said.

Big sticks and silver bullets

McCabe pointed out that if a vaccine manufacturer refuses to accept a reasonable price offer, the could choose to trigger emergency national patent legislation, which was amended at the beginning of the COVID-19 crisis.

"If a patentee refuses to agree to a reasonable price for the use of a drug or technology, and the technology is clearly important to our national security, then the government can issue a compulsory license and enter into an agreement with another organization to manufacture and supply it," he explained.

"That's an important stick the government has in the corner whilst they're negotiating prices," he said.

The Trudeau government recently signed on to a letter from world leaders encouraging global co-operation to ensure a vaccine is manufactured and distributed fairly worldwide. Canada has also put its name forward as one of 75 developed countries that would pay for a vaccine with public financing and help donate a supply to 90 developing countries.

McCabe said this approach makes sense for Canada because our country will be vulnerable to more outbreaks unless global immunity is achieved.

"We need to enter into an agreement that ensures global access (to a vaccine) because either everyone is protected against COVID-19 or no one is fully protected," he explained.

As the race to develop an effective vaccine continues, McCabe encouraged individuals to comply with and support recommended public health measures such as social distancing, handwashing and masking, as well as careful reopening of schools with robust testing and tracking capacity to contain outbreaks.

"Often it's not a shiny bit of science, it's not a silver bullet, but rather it's low-level, everyday behaviors that are going to make a massive difference," he said.

"We had to shut down in order to get a chance to get this thing under control," McCabe said. "We now have to do everything necessary to get the right behaviors so that we can reopen again so society can start to recover. And that's not going to be solved in a lab."


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Citation: Multiple factors will influence pricing for COVID-19 vaccine in Canada, says health economist (2020, September 3) retrieved 19 September 2020 from https://medicalxpress.com/news/2020-09-multiple-factors-pricing-covid-vaccine.html
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