Nanoparticle flu vaccine blocks seasonal and pandemic strains

Nanoparticle flu vaccine blocks seasonal and pandemic strains
A depiction of a nanoparticle vaccine that contains proteins from many different flu strains. Credit: UW Medicine Institute for Protein Design

Researchers have developed experimental flu shots that protect animals from a wide variety of seasonal and pandemic influenza strains. The vaccine product is currently being advanced toward clinical testing. If proven safe and effective, these next-generation influenza vaccines may replace current seasonal options by providing protection against many more strains that current vaccines do not adequately cover.

A study detailing how the new flu vaccines were designed and how they protect mice, ferrets, and nonhuman primates appears in the March 24 edition of the journal Nature. This work was led by researchers at the University of Washington School of Medicine and the Vaccine Research Center part of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health.

Influenza causes an estimated 290,000-650,000 deaths per year. Available flu vaccines, which need to be taken seasonally, often fail to protect against many circulating flu strains that cause illness, and the threat of another pandemic looms.

"Most flu shots available today are quadrivalent, meaning they are made from four different flu strains. Each year, the World Health Organization makes a bet on which four strains will be most prevalent, but those predictions can be more or less accurate. This is why we often end up with 'mismatched' flu shots that are still helpful but only partially effective," said lead author Daniel Ellis, a research scientist in the laboratory of Neil King. King is an assistant professor of biochemistry at the UW School of Medicine and a researcher at the Institute for Protein Design at UW Medicine.

Neil King of the Department of Biochemistry at the University of Washington School of Medicine and a research at the UW Medicine Institute for Protein Design describes the development of an experimental nanoparticle vaccine against a variety of seasonal and pandemic influenza strains. Credit: Randy Carnell/UW Medicine

To create improved influenza vaccines, the team attached hemagglutinin proteins from four different influenza viruses to custom-made protein nanoparticles. This approach enabled an unprecedented level of control over the molecular configuration of the resulting vaccine and yielded an improved compared to conventional flu shots. The new nanoparticle vaccines, which contain the same four hemagglutinin proteins of commercially available quadrivalent influenza vaccines, elicited neutralizing antibody responses to vaccine-matched strains that were equivalent or superior to the commercial vaccines in mice, ferrets, and nonhuman primates. The nanoparticle vaccines—but not the commercial vaccines —also induced protective antibody responses to viruses not contained in the vaccine formulation. These include avian influenza viruses H5N1 and H7N9, which are considered pandemic threats.

"The responses that our gives against strain-matched viruses are really strong, and the additional coverage we saw against mismatched could lower the risk of a bad flu season," said Ellis.


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More information: Quadrivalent influenza nanoparticle vaccines induce broad protection, Nature (2021). DOI: 10.1038/s41586-021-03365-x
Journal information: Nature

Citation: Nanoparticle flu vaccine blocks seasonal and pandemic strains (2021, March 24) retrieved 19 April 2021 from https://medicalxpress.com/news/2021-03-nanoparticle-flu-vaccine-blocks-seasonal.html
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