All gas, no brakes: Testosterone may act as 'brake pedal' on immune response

All gas, no brakes: Testosterone may act as 'brake pedal' on immune response
Jonathan Busada, a researcher with the WVU School of Medicine and Cancer Institute, has investigated the role that hormones play in male and female inflammatory responses. In a new animal study, he found that testosterone may protect against stomach inflammation. His findings appear in the journal Gastroenterology. Credit: WVU Photo/Brian Persinger

Autoimmune diseases have something in common with horses, bachelor's degrees and daily flossing habits: women are more likely to have them.

One reason for ' prevalence in may be sex-based differences in . In a new study, West Virginia University researcher Jonathan Busada investigated how sex hormones affect stomach inflammation in males and females. He found that androgens—or —may help to keep stomach inflammation in check.

"Stomach cancer is primarily caused by rampant inflammation," said Busada, an assistant professor in the School of Medicine and researcher with the Cancer Institute. "The overarching theme of my lab is to understand what's controlling the balance between a protective immune response, which is just targeting the infection, and a pathogenic immune response, which is like a toddler throwing a temper tantrum and damaging everything. It looks like androgens may be really important in tipping that balance toward a protective response."

His findings appear in Gastroenterology.

Busada's study focused on testosterone, the primary male sex hormone.

The study also considered glucocorticoids—steroid hormones that the adrenal glands secrete. Unlike testosterone, glucocorticoids are not sex hormones. Their production doesn't differ substantially between women and men.

Glucocorticoids are "the chief anti-inflammatory hormones that your body produces," Busada said. "You can think of them as the brake pedal to the immune system."

In researching mice without either glucocorticoids or testosterone, Busada, his research partner John Cidlowski—a senior investigator with the National Institutes of Health—and their colleagues observed that males' stomach inflammation increased as much as the females' did.

What's more, when he and his team gave testosterone to the female mice, their inflammation vanished.

"We were able to completely rescue them from their stomach inflammation," Busada said. "We proved that androgens were the hormones giving male mice that double layer of protection from inflammation. In the females, the only anti-inflammatory was glucocorticoids. In males, it could be either glucocorticoids or androgens. This study potentially explains why women have a much of autoimmune and chronic inflammatory diseases."

For instance, is two to three times as common in women as in men. Multiple sclerosis and rheumatoid arthritis are three times as common. Thyroid problems? Five to eight times.

"Actually, eight out of 10 individuals with autoimmune disease are women," Busada said.

Based on these research findings, clinicians may consider whether disruptive glucocorticoid or androgen signaling is contributing to their patients' stomach-inflammatory diseases.

"If someone presents with stomach inflammation, it might be worth it for clinicians to investigate what's going on with their endocrine system," Busada said.

And that's not only the case if the patient is a woman. Even though women are more susceptible to chronic stomach-inflammatory diseases, men are more susceptible to , of which inflammation is the biggest cause.

Worldwide, stomach cancer is the fifth most common form of cancer and the third leading cause of cancer deaths.

"Persistent, smoldering inflammation over the course of many, many years is the fertile ground for stomach cancer to grow." Busada said. "It's an important and understudied human health issue."

"These findings may help us understand how inflammation promotes cancer development, but we can't make any direct inferences about cancer from this body of work," he said. "That's the direction we're moving in, though. We're currently studying how sex affects carcinogenesis using an actual model."


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More information: Jonathan T. Busada et al, Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation, Gastroenterology (2021). DOI: 10.1053/j.gastro.2021.04.075
Journal information: Gastroenterology

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