Secretin hormone induces satiation by activating brown fat

Secretin hormone induces satiation by activating brown fat
Positron emission tomography images showing glucose tracer uptake after placebo and secretin infusions. Arrows show the location of brown adipose tissue. Credit: University of Turku

Researchers from the Turku PET Centre and Technical University of Munich have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue.

Brown adipose tissue is known for its ability to generate heat in response to cold exposure. Its activity has been proven to be connected to and as well as lesser risks of cardiovascular diseases. Meals have also been shown to increase the thermogenesis in brown fat, but the significance of this phenomenon has been unclear.

"Secretin is a hormone secreted into by the intestines, and it stimulates the production of peptic juices in the pancreas when we have meals. In our research, we discovered secretin receptors in the of healthy people, which suggested that secretin also affects brown fat. Secretin infusions not only increased glucose uptake in brown adipose tissue, but also elevated in the whole body," says and cardiologist Sanna Laurila from the University of Turku.

Using imaging, the researchers discovered that secretin also decreased the activity of the reward system in the brain when the subjects were looking at photos of delicious food. The subjects' decreased appetite could also be verified with a questionnaire survey, and the time between their meals grew by 40 minutes.

Brown fat generates great interest from the perspective of weight control because it has the ability to burn fat instead of storing it. However, humans have a relatively small amount of brown fat, which means that the metabolic advantages probably cannot be solely ascribed to increased energy consumption.

Secretin hormone induces satiation by activating brown fat
fMRI images, showing diminished activity of reward circuits during a food cue task after secretin infusion. Credit: University of Turku

"This newly-confirmed message chain affecting satiation in people can be one of the reasons behind the beneficial metabolic effects of brown fat," sums Professor Pirjo Nuutila.

"This study underlines the functional relevance of human in controlling energy balance as it affects both food intake and energy expenditure," says Professor Martin Klingenspor from the Technical University of Munich.

The newly discovered mechanism controlling satiation opens up new opportunities for the research of the development, prevention and treatment of obesity. Further research is needed to investigate in more detail what kind of role secretin has in metabolic disorders such as metabolic syndrome, obesity and type 2 diabetes.

In 2018, researchers from the Technical University of Munich and the Turku PET Centre discovered a new mechanism in mice that mediated via brown adipose tissue and impacting satiation, and the research results were published in the journal Cell.

The most recent research findings have been published in the journal Nature Metabolism.


Explore further

Gut hormone and brown fat interact to tell the brain it's time to stop eating

More information: Secretin activates brown fat and induces satiation. Nature Metabolism. doi.org/10.1038/s42255-021-00409-4

Yongguo Li et al, Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation, Cell (2018). DOI: 10.1016/j.cell.2018.10.016

Journal information: Nature Metabolism , Cell

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