Listening to mix of sounds and silence preserves temporal sound processing in mice

Listening to mix of sounds and silence preserves temporal sound processing in mice
Augmented auditory environments reduce hair cell loss in mice with congenital hearing loss. Credit: Dziorny et al., eNeuro 2021

Broadband sounds embedded with short pauses can maintain temporal sound processing in a mouse model of hearing loss, according to new research published in eNeuro.

Hearing loss treatments supplement auditory system function but don't repair it. However a new —playing broadband sounds during the onset of hearing loss—may be able to prevent the damage from ever occurring. Augmented auditory environments have been able to preserve auditory processing of a wide range of sound frequencies in mice models. In a new study, Dziorny et al. modified the traditional paradigm and preserved the processing of time-related, or temporal, sound features which are vital for understanding speech.

The research team exposed mice with congenital hearing loss to traditional augmented auditory , and a new one with almost undetectable gaps of silence. After 12 hours of exposure per day for 20 to 22 days, the team tested the animals' response to sound in their brainstems, cochleas, and midbrains. Both interventions preserved processing function in all three areas compared to mice that didn't receive treatment. They also prevented hair cells from dying. But the version with gaps went even further: it maintained the ability to process temporal qualities of sounds.

Augmented auditory environments show promise as non-invasive intervention to minimize the effects of congenital loss.


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More information: Rescuing Auditory Temporal Processing With a Novel Augmented Acoustic Environment in an Animal Model of Congenital Hearing Loss, eNeuro, DOI: 10.1523/ENEURO.0231-21.2021
Citation: Listening to mix of sounds and silence preserves temporal sound processing in mice (2021, June 21) retrieved 31 July 2021 from https://medicalxpress.com/news/2021-06-silence-temporal-mice.html
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