Antibiotics in early life could affect brain development

Antibiotics in early life could affect brain development
Lead author Martin Blaser, director of the Center for Advanced Biotechnology and Medicine at Rutgers. Credit: Rutgers University

Antibiotic exposure early in life could alter human brain development in areas responsible for cognitive and emotional functions, according to a Rutgers researcher.

The , published in the journal iScience, suggests that penicillin changes the microbiome—the trillions of beneficial microorganisms that live in and on our bodies—as well as , which allows cells to respond to its changing environment, in key areas of the developing brain. The findings suggest reducing widespread antibiotic use or using alternatives when possible to prevent neurodevelopment problems.

Penicillin and related medicines (like ampicillin and amoxicillin) are the most widely used antibiotics in children worldwide. In the United States, the average child receives nearly three courses of antibiotics before the age of 2. Similar or greater exposure rates occur in many other countries.

"Our previous work has shown that exposing young animals to antibiotics changes their metabolism and immunity. The third important development in involves the brain. This study is preliminary but shows a correlation between altering the microbiome and changes in the brain that should be further explored," said lead author Martin Blaser, director of the Center for Advanced Biotechnology and Medicine at Rutgers.

The study compared mice that were exposed to low-dose penicillin in utero or immediately after birth to those that were not exposed. They found that mice given penicillin experienced substantial changes in their intestinal microbiota and had altered gene expression in the frontal cortex and amygdala, two key areas in the brain responsible for the development of memory as well as fear and stress responses.

A growing body of evidence links phenomena in the with signaling to the brain, a field of study known as the "gut-brain-axis." If this pathway is disturbed, it can lead to permanent altering of the brain's structure and function and possibly lead to neuropsychiatric or neurodegenerative disorders in later childhood or adulthood.

"Early life is a critical period for neurodevelopment," Blaser said. "In recent decades, there has been a rise in the incidence of childhood , including autism spectrum disorder, attention deficit/hyperactivity disorder and learning disabilities. Although increased awareness and diagnosis are likely contributing factors, disruptions in cerebral gene expression early in development also could be responsible."

Future studies are needed to determine whether antibiotics directly effect brain development or if molecules from the microbiome that travel to the brain disturb gene activity and cause cognitive deficits.

The study was conducted along with Zhan Gao at Rutgers and Blaser's former graduate student Anjelique Schulfer, as well as Angelina Volkova, Kelly Ruggles, and Stephen Ginsberg at New York University, who all played important roles in this joint Rutgers-New York University project.

Journal information: iScience
Provided by Rutgers University
Citation: Antibiotics in early life could affect brain development (2021, July 14) retrieved 28 March 2024 from https://medicalxpress.com/news/2021-07-antibiotics-early-life-affect-brain.html
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