Harnessing the brain's plasticity to acquire epilepsy resilience

Harnessing the brain's plasticity to acquire epilepsy resilience
Epilepsy resilience can be created by enhancement of suppressive system. Credit: Ko Matsui

Around 1 percent of the world's population lives with epilepsy; yet only 65 percent of epilepsy patients can manage their symptoms with medication. Currently, surgically removing the lesion in the brain responsible for the condition is the only radical cure for epilepsy. Still, many patients have to take medication for the rest of their life to deal with their seizures.

A research group led by professor Ko Matsui from the Super-network Brain Physiology Lab at Tohoku University reported on a stimulation paradigm used on experimental animals that could potentially cultivate resilience to .

Frequent seizure-evoking stimulation to the has been shown to induce epileptogenesis and epileptic brain conditions. To the researcher's surprise, however, repeated stimulation resulted in a dramatic decrease in the seizure response to the stimulus.

"Our brain has an infinite ability for plasticity," says Matsui. "If an epileptic state can be created, we must query whether it is also conceivable to reverse the transition or to override the existing hyper-excitable circuit with an additional suppressive system."

Using optogenetics technology to control the activity, Dr. Yoshiteru Shimoda, Matsui and their team demonstrated that a specific stimulation paradigm prompted the release of the endogenous inhibitory transmitter adenosine from . This converted the rat's brain to a state strongly resistant to seizures.

Details of their findings were published in Neurobiology of Disease.

Matsui is cautiously optimistic. "Although epileptogenesis unfortunately could not be reversed, we showed we could invoke the homeostatic nature of the brain circuit to contain hyper-excitation."

For the current study, light-sensitive proteins were genetically expressed in neurons to regulate moderate neuron-to-glial signaling at will. Such optogenetic technology would be difficult to apply in , noted Matsui.

"Despite being a long way off, it is possible to imagine a future where a therapeutic strategy can directly target glial cells and enable the creation of an epileptic resistant state."


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More information: Yoshiteru Shimoda et al, Optogenetic stimulus-triggered acquisition of seizure resistance, Neurobiology of Disease (2021). DOI: 10.1016/j.nbd.2021.105602
Journal information: Neurobiology of Disease

Provided by Tohoku University
Citation: Harnessing the brain's plasticity to acquire epilepsy resilience (2022, January 17) retrieved 28 May 2022 from https://medicalxpress.com/news/2022-01-harnessing-brain-plasticity-epilepsy-resilience.html
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