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Cholesterol and inflammation demonstrate Alzheimer's link

Cholesterol and inflammation demonstrate Alzheimer's link
Reduced ABCA7 protein levels after cholesterol depletion in human C20 and HMC3 microglia cells. (A) C20 cells treated with the indicated concentrations of MβCD for 45 min and then kept in 5 μM rosuvastatin without FBS for 24 h had significantly lower cholesterol concentrations. The 10 mM MβCD/5 μM rosuvastatin treatment significantly reduced the levels of ABCA7 (B,C) and LRP1 (B,F), and significantly increased the levels of mLDLR (B,D) and pLDLR (B,E). (B) ABCA1 expression was at the limit of detection before and after the treatment. (G,H) HMC3 cells depleted in cholesterol using the 10 mM MβCD/5 μM rosuvastatin treatment had significantly lower levels of ABCA7 and LRP1 protein. Statistical analysis in (A)—ordinary ANOVA; (CF)—paired t-test for the ratio values (the experiments are numbered in the estimation plots, n = 4) and unpaired t-test for the changes in the protein expression on the percentage basis with the average value in the controls set at 100%; (H)—t-test. Credit: Cells (2023). DOI: 10.3390/cells12172143

High cholesterol and chronic inflammation are suspected to increase the risk of developing Alzheimer's Disease; however, these two factors remain poorly understood.

A recent study shows that a protein called ABCA7 plays a functional role as a potential biological link between cholesterol and in Alzheimer's disease. The new work was published online August 25 in the journal Cells.

With research performed at the Alzheimer's Center at Temple University (ACT), under the leadership of Domenico Pratico, M.D., Director of ACT, and Nicholas Lyssenko, Ph.D., the paper reports on the effects of cholesterol depletion and inflammation on ABCA7, a cellular transporter that regulates the way molecules pass through cell membranes.

The findings demonstrate the sophisticated tuning and regulation of ABCA7 levels during inflammation and reduction of cholesterol availability. The authors suggest that removal of lipids accumulated in neural cells may be a routine action of ABCA7, which, if not performed, can lead to neurodegeneration. Additionally, the study suggests that a loss of ABCA7 in Alzheimer's disease could occur either because of a sudden change in , or because of inflammation onset in microglia and astrocytes, which are neuronal supporting cells.

Previous work showed that ABCA7 levels in the brain decline with aging, and mutations that cause a loss of its function are reported in Alzheimer's disease patients. The current study provides new clues on the role of ABCA7 in Alzheimer's disease, suggesting it could be exploited for the development of new treatments.

More information: Joel P. Wiener et al, Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA, Cells (2023). DOI: 10.3390/cells12172143

Provided by Alzheimer's Center at Temple University Lewis Katz School of Medicine
Citation: Cholesterol and inflammation demonstrate Alzheimer's link (2023, September 19) retrieved 21 June 2024 from
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