This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

proofread

Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness

 Phototherapy of Alzheimer’s disease during sleep
Photobiomodulation of brain cleansing of beta-amyloid during sleep. Credit: Frontiers Journals

Photobiomodulation during sleep turns the brain into a washing machine, helping to cleanse its tissues of toxic beta-amyloid and increase resistance to the progression of Alzheimer's disease.

It is well known that is the best medication. However, it is still unknown why the brain recovers better in sleep and whether these processes can be controlled.

Recent discoveries have shown that the lymphatic system of the brain is activated during sleep, which contributes to the removal of metabolites, toxins and unnecessary molecules from its tissues. Sleep disturbance contributes to the deposition of metabolites in the central nervous system (CNS). For example, sleep is a biomarker for the development of Alzheimer's disease. This is due to the fact that the toxic metabolite beta-amyloid is excreted from brain tissue during sleep.

Sleep deprivation leads to the accumulation of toxin in the CNS, which over time can lead to the development of Alzheimer's disease.

A study, titled "Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness: the role of the meningeal lymphatics," was published in Frontiers of Optoelectronics on Sep. 18, 2023.

In this , the researchers have shown that non-invasive sleep photobiomodulation technology can effectively increase lymphatic excretion of beta-amyloid from the brain tissues of mice with Alzheimer's disease. At the same time, photobiomodulation in sleep has more significant therapeutic effects than in wakefulness.

More information: Semyachkina-Glushkovskaya Oxana et al, Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness: the role of the meningeal lymphatics, Frontiers of Optoelectronics (2023). DOI: 10.1007/s12200-023-00080-5

Provided by Frontiers Journals
Citation: Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness (2023, September 22) retrieved 23 July 2024 from https://medicalxpress.com/news/2023-09-mechanisms-phototherapy-alzheimer-disease.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Sleep and Alzheimer's disease connection

0 shares

Feedback to editors