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Researchers discover potential treatment for nicotine dependence

Researchers discover potential treatment for nicotine dependence
Individualized functional neuronavigation targets laying on the right inferior frontal gyrus during successful inhibitory control. The distribution of each participant’s peak inhibitory control GoGo/NoGo task-related blood oxygenation level-dependent response on the right inferior frontal gyrus (rIFG) during correct responses to NoGo trials while controlling for lapses in attention and novelty detection at the baseline non-stimulation control session (θ = rIFG pars opercularis [n = 32]; τ = rIFG pars triangularis [n = 5]).

New research from the University of Missouri School of Medicine suggests there may be another way to treat cigarette cravings. Researchers found that theta-burst transcranial magnetic stimulation (TBS)—strong, rapidly fluctuating magnetic field pulses that can affect brain activity—can lead to improved self-control, reduced cravings and as a result, less smoking.

People with tend to have significant structural and functional differences in the brain, compared to healthy non-smokers. Smoking cigarettes has been shown to be associated with less gray matter, which means they have less neurons and other cells in the brain.

Research suggests these differences may affect (IC), which is our control over automatic urges and response to stimuli—what enables humans to stop an impulsive reaction to something.

"Having difficulties with IC may make it harder to avoid when the urge arises, in response to all the cues and contexts in the environment that trigger the behavior to light a cigarette," said lead author Brett Froeliger, Ph.D., professor of Psychiatry.

TBS refers to when magnetic pulses are applied to the brain in bursts of three and come in two forms: continuous TBS (cTBS) and intermittent TBS (iTBS). cTBS consists of applying these three bursts repeatedly for 40 seconds, whereas iTBS applies the same number of pulses irregularly for more than 190 seconds.

Magnetic stimulation has been used to treat other mental illnesses and disorders. cTBS has been experimentally tested to treat generalized anxiety disorder, whereas iTBS to the left dorsolateral prefrontal cortex—a part of your brain responsible for —is FDA-approved for treating major depressive disorder.

The study involved 37 participants, mostly in their late 40's, and examined the effects of both cTBS and iTBS to the right inferior frontal gyrus, a brain region heavily involved with IC. Researchers found that cTBS improved IC, whereas both cTBS and iTBS reduced cravings and, subsequently, smoking.

"Identifying treatments that improve IC may help reduce smoking and can potentially help with preventing relapse following when a person attempts to quit smoking," Froeliger said. "Treatments that improve IC may also help disrupt the cycle of drug use among individuals with other ; however, further research is needed to examine the clinical value of TBS for treating substance use disorders."

"Effects of Hyperdirect Pathway Theta-Burst Transcranial Magnetic Stimulation on Inhibitory Control, Craving, and Smoking in Adults with Nicotine Dependence: A Double-Blind Randomized Crossover Trial" was recently published in Biological Psychiatry CNNI.

In addition to Froeliger, study authors include Muaid Ithman, MD, associate professor of clinical psychiatry; MU Ph.D. student Spencer Upton; TBS technician and data analyst Alexander Brown and other researchers from the University of South Carolina and Stanford University. The authors claim no conflicts of interest.

More information: Spencer Upton et al, Effects of Hyperdirect Pathway Theta-Burst Transcranial Magnetic Stimulation on Inhibitory Control, Craving, and Smoking in Adults with Nicotine Dependence: A Double-Blind Randomized Crossover Trial, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2023). DOI: 10.1016/j.bpsc.2023.07.014

Citation: Researchers discover potential treatment for nicotine dependence (2023, September 20) retrieved 1 March 2024 from https://medicalxpress.com/news/2023-09-potential-treatment-nicotine.html
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