A team of scientists at the Broad Institute of MIT and Harvard has generated one of the first comprehensive maps of cell types in a mammalian brain using recently developed technology called spatial transcriptomics, which ...
Dec 13, 2023
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The immune system can carry out many biological processes, from killing viruses to fighting cancer, thanks in large part to approximately 100 key cell-signaling proteins called cytokines, which instruct immune cells what ...
Dec 7, 2023
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Cancer immunotherapy drugs called PD-1 inhibitors are widely used to stimulate the immune system to fight cancer, but many patients either don't respond or develop resistance to them. A new small-molecule drug candidate being ...
Oct 4, 2023
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Most Alzheimer's disease research on human brain tissue has studied postmortem samples, making it difficult for scientists to discern the earliest events in the brain that might have triggered the buildup of plaques and the ...
Sep 29, 2023
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Scientists using machine learning tools to analyze biomedical data often turn to neural network algorithms, but before these models became popular, another simpler type of machine learning algorithm called kernel methods ...
Sep 11, 2023
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Researchers have identified common and rare gene mutations that increase risk for schizophrenia. Yet it's unclear what biological mechanisms go awry in the brain to cause psychosis and other disabling symptoms, due in part ...
Sep 1, 2023
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Over the past decade, researchers have been developing polygenic scores—calculations of a person's likelihood of getting a disease based on the millions of small genetic differences across their genome. The accuracy of ...
Jul 7, 2023
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The vast majority of cancer cells have too few or too many copies of some chromosomes, a state known as aneuploidy. But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply ...
Jun 29, 2023
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Friedreich's ataxia is a rare, inherited disease that causes progressive nervous system damage, impairing balance and coordination and leaving patients unable to walk by early adulthood.
Jun 22, 2023
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Researchers have uncovered the mechanism through which a single DNA base change dramatically raises the risk of a subform of type 2 diabetes (T2D) called metabolically obese normal weight (MONW). This genetic variant, which ...
May 31, 2023
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