A Ludwig Cancer Research study has identified a combination of three existing drugs that significantly extends survival in mouse models of the lethal brain cancer glioblastoma multiforme (GBM).
Sep 20, 2022
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The molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "double positive" CD4+-CD8+ T cells have lately been discovered in people in various ...
Sep 20, 2022
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The microphthalmia-associated transcription factor (MITF) is the master regulator of pigment cell development and, as a lineage survival oncogene, plays a crucial role in the skin cancer melanoma and its resistance to therapy. ...
Oct 2, 2023
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The cells of a subset of myeloproliferative neoplasms (MPNs), slow-growing blood cancers, have frameshift mutations in their calreticulin (CALR) gene that are associated with the disease. The tail end of this gene's mutated ...
Sep 20, 2022
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Natural killer (NK) cells have lately become a hot focus of efforts to develop new immunotherapies. Researchers led by Ludwig Harvard's Tony Letai, whose team collaborated closely with the Ludwig Harvard Kai Wucherpfennig ...
Sep 20, 2022
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A new study has found that the circadian clock—which synchronizes physiological and cellular activities with the day-night cycle and is generally thought to be tumor suppressive—in fact has a contextually variable role ...
Jan 24, 2024
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A team led by Ludwig Stanford's Laura Attardi explored novel mechanisms by which the p53 protein, often called the guardian of the genome, regulates gene expression by looking for novel proteins that interact with the versatile ...
Sep 20, 2022
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A Ludwig Cancer Research study conducted in both mice and a small group of patients with advanced cancers has shown that so-called "cold" tumors that are nearly devoid of immune cells—and therefore unresponsive to immunotherapy—can ...
Sep 10, 2021
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Through an analysis of tumor samples collected over time from patients with advanced melanoma, a Ludwig Cancer Research study has identified a set of preexisting conditions in tumors that predict whether such patients are ...
Feb 6, 2024
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In a May publication in iScience, researchers led by Ludwig Johns Hopkins's Ashley Cook, Nicolas Wyhs, Kenneth Kinzler and Shibin Zhou described their creation of a panel of isogenic—or genetically identical—cell lines ...
Sep 20, 2022
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