Hyperdiploidy is a genetic condition observed in cancer cells, where the cells contain more chromosomes than usual. The condition is particularly prevalent in childhood B-cell acute lymphoblastic leukemia (B-ALL), the most ...
Sep 20, 2023
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As many as 5.8 million Americans are currently living with Alzheimer's disease, a neurodegenerative condition associated with progressive cognitive decline, including loss of memory capabilities. Protein aggregates, composed ...
Sep 7, 2023
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Most new cancer cases are treated with chemotherapy, but humans naturally express proteins that indiscriminately remove chemotherapy drugs from many cells—including tumor cells, which reduces treatment efficacy.
Aug 21, 2023
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St. Jude Children's Research Hospital scientists, in collaboration with the Institute of Environmental Science and Research (ESR) Limited, found that immune cells present in people months before influenza (flu) infection ...
Aug 17, 2023
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Pediatric Early Warning Systems (PEWS) are quality improvement tools to help identify clinical deterioration in hospitalized children. Investigators from St. Jude Children's Research Hospital, together with partners across ...
Jul 10, 2023
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Scientists at St. Jude Children's Research Hospital created a hepatoblastoma (liver cancer) model that more accurately reflects the pathology and genomics of the disease. Research using the model pointed toward potential ...
Jul 7, 2023
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Scientists at St. Jude Children's Research Hospital found immune and tumor cells compete over glutamine, a major nutrient in their local environment, with significant implications for anti-cancer activity. If cancer cells ...
Jul 5, 2023
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Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease (SCD) and beta thalassemia. These two common life-threatening anemias afflict millions of individuals across the globe.
Jun 29, 2023
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Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme. Free heme can cause significant inflammation and organ damage, leading to ...
Jun 1, 2023
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Despite the astounding advances made in understanding the biologic underpinnings of cancer, many cancers are missing obvious genetic drivers. When scientists can't pinpoint the factors that drive cancer, treating it can be ...
May 4, 2023
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