Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer. How the elevated ISG15 pathway contributes to tumorigenic phenotypes remains unclear and ...
Jan 11, 2012
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Half of all women will experience the pain and burning of a urinary tract infection (UTI) at some point in their lives. Most such infections can be successfully treated with antibiotics, but antibiotic resistance – the ...
Mar 8, 2018
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In neurons, changes in the size of dendritic spines—small cellular protrusions involved in synaptic transmission—are thought to be a key mechanism underlying learning and memory. However, the specific way in which these ...
May 18, 2021
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University of Michigan researchers have determined how a gene that is known to be defective in Down syndrome is regulated and how its dysregulation may lead to neurological defects, providing insights into potential therapeutic ...
Jun 5, 2013
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Measuring the blood plasma levels of an enzyme called PDIA1 could one day become a method of diagnosing a person's predisposition to cardiovascular disease even if they are not obese, diabetic or a smoker, and with normal ...
May 20, 2019
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Cancer cells remain clumped together via a sort of 'Velcro' which allows them to adhere to each other wherever they appear. In order for cancer cells to leave a tumour and spread throughout the body during metastatic processes, ...
May 13, 2020
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Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers.
Mar 15, 2013
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Targeted cancer drugs are widely used because of their ability to inhibit specific proteins involved in cancer development with fewer side effects compared to chemotherapy drugs. But targeted therapies can often inhibit other ...
Oct 16, 2023
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The WTX gene is mutated in approximately 30 percent of Wilms tumors, a pediatric kidney cancer. Like many genes, WTX is part of a family. In this case, WTX has two related siblings, FAM123A and FAM123C. While cancer researchers ...
Aug 30, 2012
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Ewing sarcomas – rare, aggressive childhood cancers – are derived from mesenchymal cells in bone and soft tissues, and children with metastatic disease have poor survival.
Oct 5, 2017
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