Alzheimer's disease & dementia

APOE E2/E2 genotype offers some protection from cognitive decline

The APOE gene—coding for a protein involved in lipid transport and implicated in the clearance of amyloid-beta, one of the proteins that builds up in the brain in Alzheimer's disease—exists in three allelic forms: E4, ...

Genetics

Unraveling the genetic determinants of small vessel vasculitis

Autoimmune disease is fundamentally a mystery: whyever should an organism systematically set out to harm itself? Now, researchers at the University of Tsukuba have identified a genetic basis for anti-neutrophil cytoplasmic ...

Genetics

Insights into the genetic architecture of penicillin allergy

Researchers announce the first robust evidence for the role of the major histocompatibility complex gene HLA-B in penicillin allergy. To identify genetic risk factors for penicillin allergy, the international team of researchers ...

Medications

Careless cancer cells may be susceptible to future drugs

Could the ability of cancer cells to quickly alter their genome be used as a weapon against malignant tumors? Researchers at Uppsala University have developed a substance that has demonstrated promising results in experiments ...

Oncology & Cancer

Algorithm based on response, biology guides neuroblastoma therapy

(HealthDay)—Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients, according to a study published online ...

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