Oncology & Cancer
New genetic risks for colon cancer uncovered in study
Researchers at Vanderbilt-Ingram Cancer Center have found new genes that put people at higher risk for colon cancer and rectal cancer.
Sep 13, 2023
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News tagged with alternative splicing
Surgery
Researchers discover a novel pathway that minimizes liver injury during transplantation
UCLA-led research describes the role that a protein called CEACAM1 plays in protecting the liver from injury during the transplantation process, potentially improving transplant outcomes. But the features that regulate this ...
Aug 2, 2023
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Neuroscience
Q&A: What role does alternative splicing play in neurodegenerative disease?
Alternative splicing, a clever way a cell generates many different variations of messenger RNAs—single-stranded RNAs involved in protein synthesis—and proteins from the same stretch of DNA, plays an important role in ...
Jun 20, 2023
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Oncology & Cancer
New computational tool identifies novel targets for cancer immunotherapy
Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, ...
May 17, 2023
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Oncology & Cancer
The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia
A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease.
Medical research
How to compensate for loss of gene function? Think alternative splicing
Living organisms have a knack for persisting in the face of challenges. For instance, when genes malfunction, organisms may be able to compensate by activating redundant genes with similar functions, called paralogs.
Feb 21, 2023
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Diabetes
'Tiny but mighty' gene fragments are crucial for maintaining blood glucose levels, shows study
When cells copy DNA to produce RNA transcripts, they include only some chunks of genetic material known as exons and throw out the rest. The resulting product is a fully-mature RNA molecule, which can be used as a template ...
Feb 9, 2023
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Oncology & Cancer
Study identifies how cancer-causing gene regulates genetic variation in prostate cancer
Researchers from Barts Cancer Institute (BCI) at Queen Mary University of London, the Italian Institute for Genomic Medicine, and the University of Milan have identified a novel role for a cancer-causing gene in controlling ...
Sep 27, 2022
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Medical research
ALS: Early disease mechanisms discovered
Currently, there is no cure for amyotrophic lateral sclerosis (ALS). Things could soon change, however. Researchers at FAU and the University of California San Diego (UCSD) have identified a protein that already displays ...
Jul 19, 2022
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Oncology & Cancer
Researchers identify splice variant biomarkers in clear cell renal cell carcinoma
Kidney cancer accounts for only 4% of all cancers in the United States; however, its incidence has more than doubled since 1975, with the most common type being clear cell renal cell carcinoma. While outcomes of patients ...
Jul 8, 2022
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