Oncology & Cancer

New way to target cancer's diversity and evolution

Scientists have revealed close-up details of a vital molecule involved in the mix and match of genetic information within cells—opening up the potential to target proteins of this family to combat cancer's diversity and ...

Neuroscience

Unique fingerprint: What makes nerve cells unmistakable?

Protein variations that result from the process of alternative splicing control the identity and function of nerve cells in the brain. This allows organisms to build a highly complex neuronal network with only a limited number ...

Neuroscience

A match made in neural heaven: How a neuron grows an axon

While the neural architecture responsible for the transmission of electrical impulses has been known for more than a century, the basic biology behind how a neuron acquires its one and only axon—a fundamental component ...

Oncology & Cancer

Mechanism explains breast cancer cell plasticity

One of the main obstacles to successfully treating breast cancer is the cells' ability to change in ways that make them resistant to treatment. Understanding the cellular mechanisms that mediate this cancer cell plasticity ...

Genetics

Unraveling a genetic network linked to autism

Donnelly Centre researchers have uncovered a genetic network linked to autism. The findings, described in the journal Molecular Cell, will facilitate developing new therapies for this common neurological disorder.

Oncology & Cancer

Hidden signs in cancer tissue

When scientists at ETH Zurich analysed very large amounts of genetic cancer data, they found previously unresearched molecular changes. These could help in developing new personalised cancer treatments.

Medical research

Alternative splicing is crucial to muscle mass maintenance

Despite the importance that changes in muscle mass have in aging, overall body metabolism and in chronic disease, we still don't fully understand the mechanisms that contribute to the maintenance of adult muscle mass.

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