The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex ...
Mar 3, 2013
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As blood stem cells age, changes in the epigenome—the system that regulates which genes are switched on and which are switched off throughout the body—alter these cells in ways that lead to reduced immune response, increased ...
Feb 15, 2013
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Dendritic cells, or DCs for short, perform a vital role for the immune system: They engulf pathogens, break them down into their component parts, and then display the pieces on their surface. This in turn signals other immune ...
Jan 22, 2013
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US doctors say they have saved a seven-year-old girl who was close to dying from leukemia by pioneering the use of an unlikely ally: a modified form of the HIV virus.
Dec 11, 2012
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(Medical Xpress)—Researchers at the Wellcome Trust Sanger Institute have identified the key gene in ensuring that our immune defences develop infection-fighting cells. No cells of the adaptive immune system - key to attacking ...
Dec 11, 2012
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(Medical Xpress)—A newly discovered gene that is essential for embryo survival could also hold the key to treating and potentially controlling chronic infections such as HIV, hepatitis and tuberculosis.
Nov 26, 2012
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DNA sequences obtained from a handful of patients with multiple sclerosis at the University of California, San Francisco (UCSF) Medical Center have revealed the existence of an "immune exchange" that allows the disease-causing ...
Nov 19, 2012
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In the first broad genetic landscape mapped of a Burkitt lymphoma tumor, scientists at Duke Medicine and their collaborators identified 70 mutations, including several that had not previously been associated with cancer and ...
Nov 12, 2012
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A University of Colorado Boulder-led team has discovered two prime targets of the Hepatitis B virus in liver cells, findings that could lead to treatment of liver disease in some of the 400 million people worldwide currently ...
Oct 22, 2012
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Reproducing a rare type of B cell in the laboratory and infusing it back into the body may provide an effective treatment for severe autoimmune diseases such as multiple sclerosis or rheumatoid arthritis, according to researchers ...
Oct 14, 2012
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