Diabetes

Genes can help predict children's risk of type 1 diabetes

A type 1 diabetes genetic score can identify infants at risk for pre-symptomatic type 1 diabetes and could be used to enroll children into type 1 diabetes prevention trials, according to a study published this week in PLOS ...

Immunology

Bystander T cells can steal the show in resolving inflammation

In Type 1 diabetes the immune system mistakenly attacks and destroys insulin-producing pancreatic cells, leaving patients dependent on lifelong insulin injections. The putative perpetrators of the attack—which are called ...

Diabetes

Toxic proteins and type 2 diabetes

Nearly a half-billion people worldwide live with type 2 diabetes. Yet despite the disease's sizeable and increasing impact, its precise causes remain murky. Current scientific thinking points to two key processes: insulin ...

Alzheimer's disease & dementia

The brain's immune system may be key to new Alzheimer's treatments

Sanford Burnham Prebys Medical Research Institute (SBP) researchers have published two new studies in Neuron that describe how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins ...

Alzheimer's disease & dementia

Redefined Alzheimer's biology has implications for drug design

Despite the 25-year focus on the build-up in brain tissues of one protein, amyloid beta, as the purported origin of Alzheimer's disease (AD), a new study argues that it is likely triggered instead by the failure of a system ...

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