Most autism spectrum disorders have a complex, multifactorial genetic component, making it difficult to find specific treatments. Rett syndrome is an exception. Babies born with this form of the disorder have mutations specifically ...
Dec 8, 2020
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Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine-learning algorithm to create human liver organoids with blood- and bile-handling systems. When implanted into mice ...
Dec 7, 2020
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The brain changes that occur at the onset of psychiatric conditions such as schizophrenia and bipolar disorder could originate from a disturbance in neuronal signaling pathways during brain development, RIKEN neuroscientists ...
Oct 30, 2020
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Measuring just a few millimeters across, clusters of cultured cells that self-assemble into three-dimensional structures may look like just tiny blobs. But these tissues, called organoids, are enabling scientists to study ...
Sep 15, 2020
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The scientists who developed the first 3-D multicellular brain organoid with a functional blood brain barrier now report that the model could be a promising platform to screen drugs that could work to control inflammation, ...
Jul 30, 2020
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The human brain is bathed in a supportive fluid called the cerebrospinal fluid (CSF) that provides nutrients and is required for proper brain function. The composition of human CSF and how it is made are poorly understood ...
Jun 12, 2020
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When brains begin developing, there are a lot of moving parts—and when mutations happen in early neurodevelopment, it can lead to disorders like macrocephaly and autism. But scientists don't know much about the ways that ...
Mar 11, 2020
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Hundreds of miniature brains were grown in the laboratories of the University of Trento to study the genetic mechanisms responsible for medulloblastoma, the most common brain cancer affecting children. The results of a collaborative ...
Jan 29, 2020
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A team of researchers at Stanford University has, for the first time, created three-dimensional organoid models of the human forebrain. In their paper published in the journal Science, the group describes growing the organoids ...
Lab-grown brain organoids developed from a patient's own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it. A new study in Cell from researchers at Penn Medicine ...
Dec 26, 2019
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