Oncology & Cancer

Study overturns dogma of cancer metabolism theory

Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, ...

Oncology & Cancer

Cancer suppressor gene links metabolism with cellular aging

The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...

Oncology & Cancer

Liver cancer: How liver cells go astray

The causes of liver cancer are manifold. In addition to metabolic disorders such as those associated with obesity, the main causes in the western world are infections with hepatitis C virus and high alcohol consumption. Although ...

Oncology & Cancer

Lipid metabolism is potential 'Achilles' heel' for cancer stem cells

Researchers have discovered a metabolic signature critical for the functioning of "cancer stem cells" that initiate tumor formation. The team also showed how to interfere with this metabolic mechanism in ovarian cancer, inhibiting ...

Neuroscience

Cancer-like metabolism makes brain grow

The size of the human brain increased profoundly during evolution. A certain gene that is only found in humans triggers brain stem cells to form a larger pool of stem cells. As a consequence, more neurons can arise, which ...

Oncology & Cancer

'Bad fat' suppresses killer T cells from attacking cancer

In order for cancer to grow and spread, it has to evade detection by our immune cells, particularly specialized "killer" T cells. Salk researchers led by Professor Susan Kaech have found that the environment inside tumors ...

Oncology & Cancer

Study unveils new way to starve tumors to death

For decades, scientists have tried to halt cancer by blocking nutrients from reaching tumor cells, in essence starving tumor cells of the fuel needed to grow and proliferate. Such attempts often have disappointed because ...

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