Protein systems, such as Ras, make up the complex signaling pathways that control whether a cell divides or, in some cases, becomes cancerous and metastasizes into other regions of the body. For example, 98 percent of pancreatic ...
Feb 18, 2018
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Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells.
May 30, 2012
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Chronic diseases often lead to fibrosis, a condition in which organ tissue suffers from excessive scarring. Researchers at the University of Zurich have now developed an immunotherapy that specifically targets the cause—activated ...
Sep 15, 2022
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Cancer cells remain clumped together via a sort of 'Velcro' which allows them to adhere to each other wherever they appear. In order for cancer cells to leave a tumour and spread throughout the body during metastatic processes, ...
May 13, 2020
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About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors. In collaboration with researchers from the Paul Scherrer ...
Feb 3, 2016
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A*STAR researchers have shown that the RASAL2 gene, which is known to inhibit tumor growth in some breast cancers, actually advances tumor formation and metastasis in more aggressive forms of breast cancer and have suggested ...
May 27, 2015
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Cancer researchers have made great strides in developing targeted therapies that treat the specific genetic mutations underlying a patient's cancer. However, many of the most common cancer-causing genes are so central to ...
Jan 23, 2018
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Researchers at Houston Methodist demonstrated that a surface protein called OX40, responsible for keeping one type of immune system cell alive, can trigger the death of liver immune cells, in turn starting a chain reaction ...
Apr 24, 2017
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The inflammatory response is a double-edged sword—it enables the body to mount a vigorous defense against infection, but can also inflict serious physiological damage if allowed to rampage uncontrolled. Patients experience ...
Sep 26, 2012
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An experimental "decoy" has provided long-term protection from infection by the pandemic virus in mice, a new study finds.
May 30, 2023
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