Genetics

Understanding cellular clock synchronization

Circadian clocks, which regulate the metabolic functions of all living beings over a period of about 24 hours, are one of the most fundamental biological mechanisms. In humans, their disruption is the cause of many metabolic ...

Genetics

How the circadian clock regulates liver genes in time and space

Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this ...

Neuroscience

Cytoplasmic traffic jam disrupts sleep-wake cycles

KAIST mathematicians and their collaborators at Florida State University have identified the principle of how aging and diseases like dementia and obesity cause sleep disorders. A combination of mathematical modeling and ...

Medical research

Researchers find how stress and the circadian clock affect sleep

A Nagoya University-led research team in Japan has found a new neural pathway that links the circadian clock, stress, and wakefulness in mammals. The team identified a neuron, called the corticotropin-releasing factor (CRF) ...

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