Oncology & Cancer

Tumor mutations may predict response to immunotherapy

Mismatch repair deficiency refers to a characteristic of some cancer cells that create a large number of mutations, or changes, in certain genes when their mismatch repair proteins are unable to correct mistakes made when ...

Oncology & Cancer

The role of 'extra' DNA in cancer evolution and therapy resistance

Glioblastoma (GBM) is the most common and aggressive form of brain cancer. Response to standard-of-care treatment is poor, with a two-year survival rate of only 15 percent. Research is beginning to provide a better understanding ...

Oncology & Cancer

How cancer metastasis happens: Researchers reveal a key mechanism

Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

HIV & AIDS

Understanding HIV's persistence

Most cells in the human body have a limited lifespan, typically dying after several days or weeks. And yet, HIV-1 infected cells manage to persist in the body for decades. Current treatment for HIV is very effective at suppressing ...

Medical research

Some mother cells kick DNA damage 'down the road' to offspring

A new University of Colorado Boulder study has shown that some dividing human cells are "kicking the can down the road," passing on low-level DNA damage to offspring, causing daughter cells to pause in a quiescent, or dormant, ...

Medical research

Study helps explain varying outcomes for cancer, Down Syndrome

Aneuploidy is a condition in which cells contain an abnormal number of chromosomes, and is known to be the cause of many types of cancer and genetic disorders, including Down Syndrome. The condition is also the leading cause ...

Genetics

MicroRNAs protect the precursors of neurons from apoptosis

Programmed cell death is an integral part of embryonic development. Exploring the regulation of the process, Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have shown that so-called microRNAs protect the precursors ...

Immunology

Anti-viral rapid reaction force

After host cells have been attacked by a virus, they present parts of the pathogen on their surface. Thanks to these virus components, the killer cells patrolling in the body (CD8+ T lymphocytes) can recognise the infected ...

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