Oncology & Cancer

Protein disguise could be new target for cancer immunotherapy

Researchers at the Francis Crick Institute have identified a protein that helps tumors evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival. The protein could become a target ...

Diseases, Conditions, Syndromes

Immune cells promote proinflammatory fatty liver disease

A particular type of dendritic cell is responsible for the tissue damage that occurs in non-alcoholic steatohepatits (NASH) in mice and humans. The dendritic cells cause aggressive, proinflammatory behavior in T cells, as ...

Medical research

Shootin1a—the missing link underlying learning and memory

In neurons, changes in the size of dendritic spines—small cellular protrusions involved in synaptic transmission—are thought to be a key mechanism underlying learning and memory. However, the specific way in which these ...

Medical research

Research uncovers shortcut dendritic cells take to lymph nodes

In its response to pathogens and vaccines, the immune system relies on dendritic cells, white blood cells that patrol the body's tissues, collect components of pathogens and vaccines and transport them via lymphatic vessels ...

Immunology

Gene editing expands to new types of immune cells

In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) ...

Medical research

Important factor in the development of dendritic cells identified

The human immune system comprises functionally specialized cellular defense mechanisms that protect the body against disease. These include the dendritic cells. Their main function is to present antigens to other immune cells, ...

Oncology & Cancer

A new method for fighting 'cold' tumors

Not all cancerous tumors are created equal. Some tumors, known as "hot" tumors, show signs of inflammation, which means they are infiltrated with T cells working to fight the cancer. Those tumors are easier to treat, as immunotherapy ...

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