Chronic back pain affects upwards of 15 million adults in the US, racking up billions in healthcare costs and lost work days. Degeneration of the discs that cushion and support vertebrae, a common occurrence of aging, is ...
Sep 3, 2021
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A recent study from University Hospitals (UH) Connor Whole Health has found that adults who initially visit a chiropractor to receive spinal manipulation for low back pain caused by disc herniation or radiculopathy (i.e., ...
Dec 19, 2022
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An experimental formulation of a hydrogel, injected into spinal discs, proved safe and effective in substantially relieving chronic low back pain caused by degenerative disc disease (DDD), according to new research to be ...
Jun 8, 2022
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TU/e spin-off NC Biomatrix BV is developing a biomaterial that will help to treat intervertebral disc degeneration in a non-invasive way. The new biomaterial (a cell-derived matrix gel) can be injected directly into the spinal ...
Jun 13, 2019
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Working from home during the COVID-19 pandemic has taken a toll on the health of many and led to increased reports of low back pain. Low back pain is the most common musculoskeletal problem that requires medical attention—an ...
Nov 30, 2021
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A new two-step technique to repair herniated discs uses hyaluronic acid gel to re-inflate the disc and collagen gel to seal the hole, essentially repairing ruptured discs like you'd repair a flat tire.
Mar 11, 2020
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A world-first study has shown that specific physical activity benefits the discs in our spines and may help to prevent and manage spinal pain.
Apr 24, 2017
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For the first time, bioengineered spinal discs were successfully implanted and provided long-term function in the largest animal model ever evaluated for tissue-engineered disc replacement. A new Penn Medicine study published ...
Nov 21, 2018
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Neurosurgery researchers at UC Davis Health System have used a new, leading-edge stem cell therapy to promote the growth of bone tissue following the removal of cervical discs -- the cushions between the bones in the neck ...
Sep 6, 2011
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A minimally invasive treatment that injects allograft disk tissue into the spine to relieve pain associated with degenerative disk disease provides significant improvement in pain and function over a sustained period, according ...
Mar 1, 2023
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PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.
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