Medical research

How diabetes drugs may work against cancer

(Medical Xpress)—For several years, a class of anti-diabetic drugs known as biguanides, has been associated with anti-cancer properties. A number of retrospective studies have shown that the widely used diabetes drug metformin ...

Diseases, Conditions, Syndromes

Genetic mutation causes lupus in mice

Yale researchers have identified a genetic mutation that leads to lupus in mice. The discovery could open the way for development of therapies that target the mutation. The study appears in Cell Reports.

Oncology & Cancer

Mutations of immune system found in breast cancers

Mutations in the genes that defend the body against cancer-related viruses and other infections may play a larger role in breast cancer than previously thought, according to a study at the University of Illinois at Chicago.

Neuroscience

RNA build-up linked to dementia and motor neuron disease

A new toxic entity associated with genetically inherited forms of dementia and motor neuron disease has been identified by scientists at the UCL Institute of Neurology. The toxin is the result of a genetic mutation that leads ...

Medical research

Novel inhibitor implicates the TORC2 kinase in genome stability

(Medical Xpress)—FMI scientists have identified a novel inhibitor, which synergizes with low-doses of other DNA damaging agents, to induce a dramatic chromosome fragmentation even in normal cells. Unexpectedly, the compound ...

Genetics

New survey of DNA alterations could aid search for cancer genes

Scanning the DNA of nearly 5,000 tumor samples, a team led by scientists at Dana-Farber Cancer Institute and the Broad Institute has identified 140 regions of scrambled genetic code believed to contain many undiscovered cancer ...

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