Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumor sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could ...
Apr 8, 2021
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54
Neurons lack the ability to replicate their DNA, so they're constantly working to repair damage to their genome. Now, a new study by Salk scientists finds that these repairs are not random, but instead focus on protecting ...
Apr 1, 2021
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236
Researchers at Princeton have determined how five cellular proteins contribute to an essential step in the life cycle of hepatitis B virus (HBV). The article describing these findings appeared March 11, 2021 in the journal ...
Mar 11, 2021
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30
Researchers at the Francis Crick Institute have found a new way to prevent some tumors from repairing their own DNA, a function that is essential for cancer cell survival. This discovery could lead to much needed new treatments ...
Dec 16, 2020
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35
An LMU team has identified an enzyme that is essential for DNA repair. Loss of this factor leads to cell death when cancer cells accumulate DNA damage. Chemical inhibition of the target protein offers a possible strategy ...
Dec 4, 2020
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219
Treatments that harness the immune system to fight cancer have greatly improved outcomes for some people with cancer. Scientists are learning more about why some people respond much better than others to these drugs.
Dec 1, 2020
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71
Sydney researchers have found cancer cells can repair their DNA by using 'cables' in their nucelus. The findings open new possibilities for designing future cancer treatments.
Dec 1, 2020
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22
Treating tumors presents a tricky conundrum: a higher dose of radiation is more effective for treatment, but the higher the dose, the more danger it poses to healthy cells.
Nov 18, 2020
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23
Scientists at St. Jude Children's Research Hospital have identified the structure of double-strand DNA break repair by PARP enzymes. The findings show that PARP2 can bridge the gap, bringing two broken DNA ends together.
Sep 16, 2020
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61
A new precision medicine targeting cancer's ability to repair its DNA has shown promising results in the first clinical trial of the drug class.
Jun 22, 2020
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