Around 98.5% of human DNA is non-coding, meaning it doesn't get copied to make proteins. A new study has connected many of these non-coding regions to the genes they affect and laid out guidelines for how researchers can ...
Mar 19, 2024
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A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new ...
Mar 19, 2024
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Researchers at the University of Toronto's Donnelly Centre for Cellular and Biomolecular Research have found two enzymes that work against the chemotherapy drug gemcitabine, preventing it from effectively treating pancreatic ...
Mar 18, 2024
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Researchers describe a newly observed role for the protein Cyclin Dependent Kinase 9 (CDK9) in regulating DNA repair during cellular division, where errors can become the origin of cancerous tumor growth. Through a process ...
Mar 14, 2024
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It's no secret that smoking is extremely detrimental to health. Tobacco smoke contains thousands of chemicals, including carcinogens, increasing the risk of cancer, cardiovascular and respiratory diseases.
Mar 14, 2024
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Repeats of DNA sequences, often referred to as "junk DNA" or "dark matter," that are found in chromosomes and could contribute to cancer or other diseases have been challenging to identify and characterize.
Mar 13, 2024
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Discovery of a DNA shift in the innate immune memory of cells may aid in the fight against one of humans' most deadly foes—sepsis.
Mar 12, 2024
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Cancer cells are characterized by their aggressiveness: they grow rapidly and spread to other parts of the body. To enable this, numerous mechanisms come into play, and one of them involves a protein called MYC, which activates ...
Mar 7, 2024
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Traumatic injuries to the peripheral nervous system are a leading cause of disability, especially in patients with proximal peripheral nerve injury. It's hard to regenerate and regain normal function in a short period, and ...
Mar 7, 2024
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Epigenetic changes play important roles in cancer, metabolic and aging-related diseases, but also during loss of resilience as they cause the genetic material to be incorrectly interpreted in affected cells. A major study ...
Mar 6, 2024
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