How do individual developing cells choose and commit to their "identity"—to become, for example, an immune cell, or a muscle cell, or a neuron?
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Atherosclerotic disease, the slow and silent hardening and narrowing of the arteries, is a leading cause of mortality worldwide. It is responsible for more than 15 million deaths each year, including an estimated 610,000 ...
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A new Nature Communications study led by University of Kentucky Markey Cancer Center researchers suggests that an enzyme known as Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) is a potential therapeutic target for triple negative ...
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We're all born with a DNA sequence that encodes (in the form of genes) the very traits that make us, us—eye color, height, and even personality. We think of those genes as unchanging, but in reality, the way they are expressed, ...
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The selection of a first-line chemotherapy drug to treat many types of cancer is often a clear-cut decision governed by standard-of-care protocols, but what drug should be used next if the first one fails?
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A group of Brazilian researchers succeeded in preventing allergic asthma from progressing in experimental models by increasing the amount of a certain protein. This increase, in turn, blocked the CD4+ T lymphocytes responsible ...
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(HealthDay)—Individuals with Alzheimer's disease (AD) have abnormalities and reductions in gene expression in the parahippocampal gyri that map to genes associated with the insulin receptor signaling pathway (IRSP), according ...
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Unleashing the immune system to fight tumors—an approach enabled by immunotherapy—has led to remarkable outcomes in some cancer patients, but in many more, cancer cells evade the treatment and continue to spread. Now, ...
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For decades, scientists have viewed the brain as a veritable black box—and now Catherine Dulac and Xiaowei Zhuang are poised to open it.
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A team of researchers affiliated with several institutions in the U.S. has identified circadian rhythm patterns in human skin based on genetic biomarkers. In their paper published in Proceedings of the National Academy of ...
