Diabetes

Insulin-sensitive fat leads to obesity

SORLA is a protein that influences the balance of metabolic processes in adipose tissue, a particular form of fat. Too much of it makes fat cells overly sensitive to insulin, which leads them to break down less fat. SORLA ...

Overweight & Obesity

SORLA controls insulin signaling to promote obesity in mice

Large-scale genetic studies have linked variations in genes and proteins to an increased risk for developing obesity. Determining how these variations alter metabolism to increase body mass may lead to the identification ...

Diabetes

Sticky molecules to tackle obesity and diabetes

Okayama University researchers report that the over-expression of an adhesion molecule found on the surface of fat cells appears to protect mice from developing obesity and diabetes. The findings, published in the journal ...

Diabetes

Single enzyme is necessary for development of diabetes

An enzyme called 12-LO promotes the obesity-induced oxidative stress in the pancreatic cells that leads to pre-diabetes, and diabetes. 12-LO's enzymatic action is the last step in the production of certain small molecules ...

Medical research

A new player in lipid metabolism discovered

(Medical Xpress)—Specially engineered mice that lacked a particular gene did not gain weight when fed a typical high-fat, obesity-inducing Western diet. Yet, these mice ate the same amount as their normal counterparts that ...

Health

Humans can use smell to detect levels of dietary fat

New research from the Monell Center reveals humans can use the sense of smell to detect dietary fat in food. As food smell almost always is detected before taste, the findings identify one of the first sensory qualities that ...

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