The tumor suppressor protein ARID1A controls global transcription in ovarian epithelial cells, according to new research conducted at The Wistar Institute, which provided mechanistic insight into tumorigenesis mediated by ...
Jun 26, 2018
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One powerful DNA-binding protein, the transcription factor PU.1, steals away other transcription factors and recruits them for its own purposes, effectively dominating gene regulation in developing immune cells, according ...
Jun 20, 2018
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Our genome contains all the information necessary to form a complete human being. This information, encoded in the genome's DNA, stretches over one to two metres long but still manages to squeeze into a cell about 100 times ...
Jan 23, 2018
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Scientists read the code of life—the genome—as a sequence of letters, but now researchers have also started exploring its three-dimensional organisation. In a paper published in Nature Genetics, an interdisciplinary research ...
Jan 16, 2018
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Preeclampsia is the most dangerous form of hypertension during a pregnancy and can be fatal for both mother and child. Though it is known to originate in the placenta, the root causes remain largely a mystery. An international ...
Oct 6, 2017
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In the current issue of Proceedings of the National Academy of Sciences, researchers from Nationwide Children's Hospital describe a new paradigm for treating transcription factor-driven cancers. The study focuses on Ewing ...
Sep 18, 2017
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Northwestern Medicine scientists have discovered the mechanism driving a protein that influences transcription, a crucial step in gene expression. The study, recently published in Science, could lead to drugs that control ...
Sep 7, 2017
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Scientists have successfully regenerated cells in the retina of adult mice at the University of Washington School of Medicine in Seattle.
Jul 26, 2017
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Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June ...
Jun 26, 2017
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The immune system is a formidable defense against microbial intruders, identifying and eliminating threats through an extremely intricate and adaptable network of specialized cells. However, a system of such deep complexity ...
May 30, 2017
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