Researchers use skin cells from patients with an inherited heart condition to recreate the adult-onset disease in a laboratory dish—producing the first maturation-based disease model for testing new therapies.
Jan 27, 2013
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Cardiac amyloidosis is a serious disease in which abnormal proteins (amyloids) accumulate in the heart muscle and impair heart function. As the disease leads to serious complications such as heart insufficiency and, in many ...
Mar 21, 2024
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A UCLA-led team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, offering a deeper understanding of how heart muscle cells develop from ...
Oct 18, 2023
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Investigators have identified more than 60 previously unknown genetic variants associated with resting heart rate that may also contribute to increased risk of cardiovascular disease, according to recent findings published ...
Sep 8, 2023
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Oxidative stress—characterized by elevated levels of unstable molecules called reactive oxygen species—is associated with neurodegeneration and cardiovascular disease. However, until recently it has not been possible ...
Jun 14, 2023
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A stem cell therapy treatment developed by Duke-NUS Medical School researchers for heart failure has shown promising results in preclinical trials. These cells, when transplanted into an injured heart, are able to repair ...
Jun 8, 2023
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Our genetic code includes more than 15,000 specific sections that can be made into molecules called lincRNAs. Some of these sections can occur in coiled-up sections of our genome called TADs. LincRNAs derived from TADs appear ...
Apr 26, 2023
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Estrogen is known to play an important role in the protection of women's hearts, but once women are postmenopausal and estrogen levels drop, they are at an increased risk of a number of diseases and conditions, including ...
Mar 10, 2023
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A team of researchers at the University of Texas Southwestern Medical Center has found that it is possible in mice to protect the heart from ischemia-reperfusion using the CRISPR-Cas9 gene editing system. In their paper published ...
Researchers at the University of Southern California Alfred E. Mann Department of Biomedical Engineering have developed a "heart attack on a chip," a device that could one day serve as a testbed to develop new heart drugs ...
Dec 7, 2022
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