Medical research

Abnormal bone formation after trauma explained and reversed in mice

Hip replacements, severe burns, spinal cord injuries, blast injuries, traumatic brain injuries—these seemingly disparate traumas can each lead to a painful complication during the healing process called heterotopic ossification. ...

Medical research

New treatment could improve care for two bone diseases

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona (UB) have described the ability of an inhibitor of the PI3Kα (BYL719) to block the ectopic bone formation in mice. This ...

Medical research

Keeping bone in its place

Heterotopic ossification (HO) is the formation of bone within soft tissue such as muscle, leading to pain and potentially the inability to use a limb. Once thought to be primarily a genetic disease, the cause of most trauma-induced ...