Phenylketonuria (PKU) is a rare newborn genetic disease that impacts between 1 in 10,000 to 1 in 20,000 people, depending on the individuals' genetic ancestry. PKU causes an amino acid—called phenylalanine (Phe)—to build ...
Nov 2, 2023
0
50
A research group from the Graduate School of Medicine and Research Institute of Environmental Medicine at Nagoya University report that cholesterol accumulation in macrophages promotes liver fibrosis in the development of ...
Sep 19, 2023
0
4
Yale researchers have created a functional "humanized" liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic liver diseases afflicting ...
Aug 9, 2023
0
0
Immune system T cells that should be able to kill cancer cells become dysfunctional or "exhausted" within hours of encountering a tumor, according to a study reported Aug. 3 in Nature Immunology.
Aug 3, 2023
0
69
A new study in Gastroenterology identifies how certain proteins in the immune system interact and lead to organ rejection. The study, which involved experiments on mice and human patients, uncovered an important communication ...
Jul 19, 2023
0
19
A mechanism underlying several liver diseases involves bile produced in the liver that cannot be secreted into the intestine as intended. This leads to a backlog of bile, which can damage the liver tissue.
Jul 3, 2023
0
72
Researchers have long been fascinated by the possibility that exercise causes various cells in our body to produce molecules that benefit human health, says Jonathan Long, assistant professor of pathology at Stanford University.
Jun 16, 2023
0
76
University of Queensland-led research has revealed liver cells influence the body's internal circadian clock, which was previously believed to be solely controlled by the brain.
May 17, 2023
0
70
A new study characterizes a bioengineered adeno-associated virus (AAV)3B capsid variant that demonstrates improved transduction to human liver cells. Another advantage of the AAV3B-V04 capsid was its significantly reduced ...
Apr 25, 2023
0
3
A new chip that holds different cell types in tiny, interconnected chambers could allow scientists to better understand the physiological and disease interactions between organs. The integrated-gut-liver-on-a-chip (iGLC) ...
Apr 7, 2023
0
51
