Neuroscience
Team finds essential clue to Huntington's disease solution
Researchers at McMaster University have discovered a solution to a long-standing medical mystery in Huntington's disease (HD).
Jul 29, 2013
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News tagged with huntingtin protein
Neuroscience
Failure to destroy toxic protein—not buildup of protein itself—contributes to Huntington's disease
Alzheimer's, Huntington's, Parkinson's. Names forever linked to what they represent: diseases that ravage the brain's neurons and leave entire regions to wither and die. These and other so-called neurodegenerative diseases ...
Jul 21, 2013
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Neuroscience
Enzyme inhibition protects against Huntington's disease damage in two animal models
Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal ...
Nov 29, 2012
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Neuroscience
Toxic protein build-up in blood shines light on Huntington's disease
A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells. Published today in the Journal ...
Sep 17, 2012
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Genetics
Cell contents may be key to controlling toxicity of Huntington's disease protein
New research into the cell-damaging effects of Huntington's disease suggests a potentially new approach for identifying possible therapeutic targets for treating the nerve-destroying disorder.
Jun 6, 2012
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Medical research
Potential new treatments for Huntington's disease
Huntington's disease is caused by repeated toxic changes in the protein huntingtin. An interdisciplinary team from the Department of Molecular Neurology and the Department of Stem Cell Biology at Universitätsklinikum Erlangen ...
Dec 8, 2022
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Medical research
Study probes function of Huntington's disease protein in injured neurons
In a new University at Buffalo-led study, scientists propose a new role for the huntingtin protein (HTT), which causes Huntington's disease when mutated.
Sep 27, 2022
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Medical research
Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein
Researchers world-wide are focused on clearing the toxic mutant Huntingtin protein that leads to neuronal cell death and systemic dysfunction in Huntington's disease (HD), a devastating, incurable, progressive neurodegenerative ...
Jun 2, 2021
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Neuroscience
Scientists move closer to treatment for Huntington's disease
A new variant of the gene-editing CRISPR/Cas9 system is safer and more specific than versions previously used in early research towards a treatment for Huntington's disease, shows research published today in Frontiers in ...
Feb 26, 2018
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Neuroscience
Potential therapeutic target for Huntington's disease
There is new hope in the fight against Huntington's disease. Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected ...
Aug 16, 2016
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