Researchers at Memorial Sloan Kettering Cancer Center, New York, have concluded their phase 2 trial of chemotherapy in combination with the drugs nivolumab, and regorafenib.
Kidney organoids provide a promising platform in vitro to model the mechanisms of kidney disease, however, they are limited by an existing lack of knowledge of their inherent functional protein expression. In a new report ...
Knowing whether a tumor might grow or spread to other parts of a patient's body could be key to survival—and now scientists are one step closer to unlocking the ability to predict just that.
Apr 13, 2023
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There are 1.5 million cases of drug-induced kidney toxicity each year in the U.S. Among the usual suspects are cyclosporin and cisplatin, a pair of widely used chemotherapy drugs. Because both are considered lifesaving therapies, ...
Just over two years ago, Melinda Bachini decided she was done with chemotherapy to treat her cholangiocarcinoma—a rare cancer of the bile duct that runs from the liver to the intestines.
May 8, 2014
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In a new analysis of genetic susceptibility to kidney cancer, an international team of researchers has identified 50 new areas across the genome that are associated with the risk of developing kidney cancer. These insights ...
7 hours ago
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A combination of immunotherapy and targeted therapies show promise in managing metastatic renal cell carcinoma (RCC), the most common form of kidney cancer that makes up 90% of all cases. However, accurately predicting responses ...
Apr 5, 2024
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To prevent an emerging genomic technology from contributing to health disparities, a scientific team has devised new ways to improve a genetic testing method called a polygenic risk score. Since polygenic risk scores have ...
Feb 19, 2024
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Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease, can lead to kidney enlargement and eventual loss of function. The disease affects more than 12 million people worldwide, ...
Jan 22, 2024
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Researchers from A*STAR's Institute of Molecular and Cell Biology (IMCB) and National Cancer Centre Singapore (NCCS) have discovered how the loss of a gene, PBRM1, can lead to the development of kidney cancer. The work is ...
Jul 28, 2023
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Kidney cancer is any cancer that originates in a kidney. The two most common types of kidney cancer, reflecting their location within the kidney, are renal cell carcinoma and renal pelvis carcinoma. The distinction between these two types is important because their most common histologies are different and consequently they respond differently to chemotherapy.
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