Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the ...
Jun 26, 2024
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A world-first research discovery from the Storr Liver Center at The Westmead Institute for Medical Research (WIMR) has identified why lean people with metabolic dysfunction-associated fatty liver disease (MAFLD) have higher ...
Jun 25, 2024
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A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) has discovered unexpected molecular heterogeneity even within the same liver ...
Jun 24, 2024
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The current method for assessing medication-related liver injury is not providing an accurate picture of some medications' toxicity—or lack thereof—to the liver, according to a new study led by researchers from the Perelman ...
Jun 24, 2024
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In an editorial, researchers Gregory L. Guzik and Ankit Mangla from University Hospitals Cleveland Medical Center, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, and Case Comprehensive ...
Jun 21, 2024
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Hepatic lipid homeostasis is critical for both cellular function and overall metabolic health. Disruptions in lipid homeostasis can lead to fatty liver diseases, which have become a significant global health concern. The ...
Jun 21, 2024
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Nonalcoholic fatty liver disease (NAFLD), now reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), and its more severe form, nonalcoholic steatohepatitis (NASH), renamed metabolic dysfunction-associated ...
Jun 21, 2024
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Hepatocellular carcinoma (HCC) presents significant challenges due to its high incidence and mortality rates, particularly in China where most patients are diagnosed at intermediate or advanced stages. This limits the applicability ...
Jun 21, 2024
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Primary sclerosing cholangitis (PSC) is a rare progressive liver disease that damages bile ducts and significantly increases the risk of bile duct cancer, particularly a type called cholangiocarcinoma (CCA). This cancer is ...
Jun 20, 2024
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More clinical research is needed to investigate how reducing alcohol consumption in patients with alcohol-related liver disease (ALD) may slow disease progression and improve outcomes, according to an international task force ...
Jun 18, 2024
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